Evidence map›Paper›PMID 38763332›Full record

ArticleThe Journal of biological chemistry2024

Immunoglobulin constant regions provide stabilization to the paratope and enforce epitope specificity.

Scott A McConnell, Arturo Casadevall

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Scott A McConnellDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. Electronic address: acasade1@jhu.edu.

Funding

Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
Conjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1M
Exploiting antibody catalysis for treating CryptococcosisR01AI162381 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2021 to 2025
$3.7M
NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI152078NIAID NIH HHS R01 AI162381NIAID NIH HHS T32 AI007417
6 · The paper itself

Abstract

Constant domains in antibody molecules at the level of the Fab (C

Indexed as

Cryptococcus neoformansEpitopesAnimalsAntibodies, FungalAntibody SpecificityHumansImmunoglobulin Constant RegionsImmunoglobulin Fab FragmentsMolecular Dynamics SimulationSingle-Chain AntibodiesAntibodies, FungalEpitopesImmunoglobulin Constant RegionsImmunoglobulin Fab FragmentsSingle-Chain AntibodiesCryptococcus neoformansepitope mappingfungal pathogensimmunoglobulinsmolecular dynamicssingle-chain variable fragments

Identifiers

PMID38763332
PMCPMC11215335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.