Evidence map›Paper›PMID 38763308›Full record

ArticleContemporary clinical trials2024

eHealth mindfulness-based music therapy for patients undergoing allogeneic hematopoietic stem cell transplantation: A pilot randomized controlled trial protocol.

Sara E Fleszar-Pavlovic, Blanca Noriega Esquives, Arianna E Brito, Ann Marie Sia, Mary Adelyn Kauffman, Maria Lopes, Patricia I Moreno, Tulay Koru-Sengul, Rui Gong, Trent Wang and 6 more

Abstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Our Brains on Art: An Ancient Prescription for 21st Century Solutions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sara E Fleszar-PavlovicSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: sef144@med.miami.edu.
Blanca Noriega EsquivesSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: bsn24@miami.edu.
Arianna E BritoSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: aeb178@med.miami.edu.
Ann Marie SiaDepartment of Undergraduate Research, University of Miami, Coral Gables, FL, USA. Electronic address: ams934@miami.edu.
Mary Adelyn KauffmanSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: m.kauffman@miami.edu.
Maria LopesDepartment of Psychology, College of Arts and Sciences, University of Miami, Coral Gables, FL, USA. Electronic address: mxl1187@miami.edu.
Patricia I MorenoDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: patricia.moreno@miami.edu.
Tulay Koru-SengulDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: tsengul@med.miami.edu.
Rui GongDepartment of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: rxg1321@miami.edu.
Trent WangDepartment of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: trentwang@med.miami.edu.
Eric D WiederDepartment of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: ewieder@med.miami.edu.
Maria Rueda-LaraDepartment of Psychiatry and Behavioral Sciences and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: mrueda2@med.miami.edu.
Michael AntoniDepartment of Psychology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: mantoni@miami.edu.
Krishna KomanduriDepartment of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Electronic address: Krishna.Komanduri@ucsf.edu.
Teresa LesiukFrost School of Music and Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, FL, USA. Electronic address: tlesiuk@miami.edu.
Frank J PenedoDepartments of Psychology and Medicine, and Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, FL, USA. Electronic address: frank.penedo@miami.edu.

Funding

Training to Reduce Burden across the Cancer Control Continuum (TRACC)T32CA251064 · NCI · UNIVERSITY OF MIAMI CORAL GABLES · PI ERIN N KOBETZ, Frank J Penedo · 2020 to 2026
$3.2M
eHealth Supported Mindfulness-based Music Therapy Intervention (eMBMT) in Hemopoietic Stem Cell Transplant PatientsR33CA263335 · NCI · UNIVERSITY OF MIAMI CORAL GABLES · PI Teresa Lynn Lesiuk, Frank J Penedo · 2025 to 2026
$874k
eHealth Supported Mindfulness-based Music Therapy Intervention (eMBMT) in Hemopoietic Stem Cell Transplant PatientsR61CA263335 · NCI · UNIVERSITY OF MIAMI CORAL GABLES · PI LESIUK, TERESA LYNN, PENEDO, FRANK J · 2022 to 2023
$866k
Patient Activation and Palliative Care among Hispanics/Latinos with Metastatic CancerK01CA258955 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MORENO, PATRICIA INGRID · 2021 to 2025
$834k
NCI NIH HHS K01 CA258955NCI NIH HHS R33 CA263335NCI NIH HHS R61 CA263335NCI NIH HHS T32 CA251064
6 · The paper itself

Abstract

backgroundAllogeneic stem cell transplantation (allo-SCT) is the preferred therapy for patients with high-risk or relapsed hematologic malignancies, but may be complicated by psychological distress (e.g., depression, anxiety) and symptom burden (e.g., fatigue, pain). Mindfulness-based music therapy (MBMT), a relatively novel integrative medicine intervention that draws from mindfulness and music therapy principles, has shown promise in improving psychosocial outcomes and symptom burden in cancer patients. We outline an eHealth-based MBMT (eMBMT) intervention protocol examining: (1) feasibility, acceptability, and intended effects of eMBMT in improving HRQOL, symptom burden, and clinical markers of disease activity (e.g., infections), and (2) the extent to which eMBMT music therapy component-associated improvements in HRQOL, symptom burden, and disease activity are mediated by improvements in psychosocial and physiological (e.g., systemic inflammation, immune recovery) adaptation.

methodsParticipants (n = 60) with a hematologic malignancy undergoing allo-SCT will be randomized to receive eMBMT or an eHealth-based mindfulness meditation (eMM) intervention. eMBMT includes eight 60-min sessions facilitated by a music therapist focusing on mindfulness and music therapy. eMM includes eight 60-min self-led MM practices.

resultsFeasibility, acceptability, HRQOL, symptom burden, disease activity, and mediation effects of psychosocial and physiological adaptation will be assessed at baseline, pre-infusion, and post-engraftment with blood collection at baseline and post-engraftment.

conclusionThe current pilot RCT is the first eMBMT intervention to address the HRQOL and symptom burden of patients who are undergoing allo-SCT. Results will inform a fully powered RCT to establish preliminary efficacy of eMBMT on improvements in HRQOL, symptom burden, and disease activity.

Indexed as

Hematologic NeoplasmsHematopoietic Stem Cell TransplantationMindfulnessMusic TherapyQuality of LifeAdultAnxietyDepressionFeasibility StudiesFemaleHumansMaleMeditationPilot ProjectsRandomized Controlled Trials as TopicTelemedicineAllogeneic stem cell transplantationBone marrow transplantHematologic malignancyMindfulnessMindfulness-based music therapyMusic therapy

Identifiers

PMID38763308
PMCPMC11244650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.