Evidence map›Paper›PMID 38763306›Full record

ArticleContemporary clinical trials2024

HPV Multilevel Intervention Strategies Targeting Immunization in Community Settings (HPV MISTICS): Study protocol for a hybrid 1 stepped-wedge cluster randomized trial.

Shannon M Christy, Lily Patel, Mariana Arevalo, Lindsay Fuzzell, Ashley Whitmer, Kea Turner, L Robert Gore, Katherine Chung-Bridges, Daniel Parras, Edelise Y Endemano and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05677360 (HPV Multilevel Intervention Strategies Targeting Immunization in Community Settings), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05677360 nasuspendednot on this map

HPV Multilevel Intervention Strategies Targeting Immunization in Community Settings (HPV MISTICS)

TypeinterventionalSponsorH. Lee Moffitt Cancer Center and Research InstituteRan2023 to 2026Enrolled564ConditionsHuman Papilloma Virus (HPV) VaccineArmsHPV MISTICS -Provider Level, HPV MISTICS - Parent Level, HPV MISTICS- HPV Vaccine Champion Level
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Development and Evaluation of an HPV Vaccine Champion Training: a Strategy to Boost Adolescent Vaccination in Community Health Centers in Florida.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shannon M ChristyDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA; Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: Shannon.Christy@moffitt.org.
Lily PatelCollege of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Mariana ArevaloDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: Mariana.Arevalo@moffitt.org.
Lindsay FuzzellDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: Lindsay.Fuzzell@moffitt.org.
Ashley WhitmerNon-Therapeutic Research Office, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: Ashley.Whitmer@moffitt.org.
Kea TurnerDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA; Morsani College of Medicine, University of South Florida, Tampa, FL, USA. Electronic address: Kea.Turner@moffitt.org.
L Robert GoreMorsani College of Medicine, University of South Florida, Tampa, FL, USA; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: lgore@adena.org.
Katherine Chung-BridgesHealth Choice Network, Inc., Miami, FL, USA. Electronic address: KChung@hcnetwork.org.
Daniel ParrasHealth Choice Network, Inc., Miami, FL, USA. Electronic address: DParras@HCNetwork.org.
Edelise Y EndemanoHealth Choice Network, Inc., Miami, FL, USA. Electronic address: EEndemano@HCNetwork.org.
Naomi C BrownsteinDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA. Electronic address: brownstn@musc.edu.
Susan T VadaparampilDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA; Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: Susan.Vadaparampil@moffitt.org.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
NCATS NIH HHS UL1 TR001450NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

backgroundThis protocol paper describes the overall design for HPV MISTICS, a multilevel intervention to increase human papillomavirus (HPV) vaccination initiation and completion rates among adolescents aged 11-17.

methodsWe will conduct a hybrid type 1 implementation-effectiveness trial using a stepped-wedge cluster randomized trial in eight federally qualified health centers (FQHCs) in Florida. Intervention components target three levels: system, providers, and parents. Outcomes will be assessed using quantitative (e.g., vaccination data, survey data) and qualitative methods (e.g., staff and parent interviews). We expect to quantify changes in HPV vaccine series initiation and completion rates for adolescents ages 11-17 in the eight FQHCs. We have hypothesized a 20-percentage point increase in HPV vaccine series initiation and a 10-percentage point increase in series completion. We also anticipate being able to explore factors at the system, provider, and patient levels as potential covariates. Implementation outcomes, barriers, and facilitators identified in the study will help characterize the implementation process and inform potential future intervention scale-up.

resultsThe project is ongoing; effectiveness and implementation outcomes will be determined following project completion.

conclusionsFindings will provide evidence of an equity-informed research design and implementation procedures that could help improve HPV vaccination rates in similar health systems. CLINICAL TRIALS IDENTIFIER: NCT05677360 (date registered: 2022-12-22); https://clinicaltrials.gov/study/NCT05677360?lead=Moffitt%20Cancer%20Center%20&aggFilters=status:rec&page=2&rank=17.

Indexed as

Papillomavirus InfectionsPapillomavirus VaccinesParentsAdolescentChildFemaleFloridaHumansMaleRandomized Controlled Trials as TopicResearch DesignPapillomavirus VaccinesCluster randomized trialHPV vaccineHybrid implementation-effectiveness trialMultilevel interventionStepped-wedge designStudy protocol

Identifiers

PMID38763306
PMCPMC11180554

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.