Evidence map›Paper›PMID 38763127›Full record

ArticleDigestion2024

Risk Factors for Post-Colorectal Endoscopic Submucosal Dissection Bleeding and Efficacy of Carbazochrome Sodium Sulfonate: A Multicenter Retrospective Cohort Study.

Keitaro Takahashi, Takuya Iwama, Kazuyuki Tanaka, Yuki Miyazawa, Shohei Kuroda, Masashi Horiuchi, Seisuke Saito, Momotaro Muto, Aki Sakatani, Katsuyoshi Ando and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestion, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Keitaro TakahashiDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Takuya IwamaDepartment of Gastroenterology, Asahikawa City Hospital, Asahikawa, Japan.
Kazuyuki TanakaDepartment of Gastroenterology, Asahikawa-Kosei General Hospital, Asahikawa, Japan.
Yuki MiyazawaDepartment of Gastroenterology, Nayoro City General Hospital, Nayoro, Japan.
Shohei KurodaDepartment of Gastroenterology, Japanese Red Cross Asahikawa Hospital, Asahikawa, Japan.
Masashi HoriuchiDepartment of Gastroenterology, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
Seisuke SaitoDepartment of Gastroenterology, Furano Kyokai Hospital, Furano, Japan.
Momotaro MutoDepartment of Internal Medicine, Engaru-Kosei General Hospital, Engaru, Japan.
Aki SakataniDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Katsuyoshi AndoDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Nobuhiro UenoDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Shin KashimaDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Kentaro MoriichiDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Hiroki TanabeDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Toshikatsu OkumuraDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Mikihiro FujiyaDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCarbazochrome sodium sulfonate (CSS) is a hemostatic agent that reduces capillary permeability and enhances capillary resistance. However, its specific effects on colorectal endoscopic submucosal dissection (ESD) outcomes remain uncertain. This study aimed to assess the risk factors for post-ESD bleeding and the effect of CSS on colorectal ESD outcomes.

methodsFirst, we retrospectively analyzed the risk factors for post-ESD bleeding using data from 1,315 lesions in 1,223 patients who underwent ESD for superficial colorectal neoplasms at eight institutions. Second, patients were divided into CSS and non-CSS groups using propensity score matching, and their outcomes from colorectal ESD were analyzed.

resultsThe risk factors for post-colorectal ESD bleeding were identified as age of ≥70 years, tumor located in the rectum, tumor size of ≥40 mm, and post-ESD defect unclosure in both univariate and multivariate analyses. The CSS and non-CSS groups each consisted of 423 lesions after propensity score matching. The post-colorectal ESD bleeding rate was 3.5% (15/423) and 3.3% (14/423) in the CSS and non-CSS groups, respectively, indicating no significant differences. Among patients with the high-risk factors for post-ESD bleeding, the administration of CSS also did not demonstrate a significant reduction in the post-ESD bleeding rate compared to the non-CSS group.

conclusionCSS administration is ineffective in preventing post-colorectal ESD bleeding in both the general population and individuals at a high risk for such bleeding. Our results indicate the necessity to reconsider the application of CSS for preventing post-colorectal ESD bleeding.

Indexed as

Colorectal NeoplasmsEndoscopic Mucosal ResectionPostoperative HemorrhagePropensity ScoreAdrenochromeAgedAged, 80 and overColonoscopyFemaleGastrointestinal HemorrhageHemostaticsHumansMaleMiddle AgedRetrospective StudiesRisk FactorsAdrenochromecarbazochromeHemostaticsBleedingCarbazochrome sodium sulfonateColonEndoscopic submucosal dissectionRisk factor

Identifiers

PMID38763127
PMCPMC11318496

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.