Evidence map›Paper›PMID 38762909›Full record

ArticleMedical physics2024

Electron beam response corrections for an ultra-high-dose-rate capable diode dosimeter.

Tianyuan Dai, Austin M Sloop, Andreas Schönfeld, Veronika Flatten, Jakub Kozelka, Jeff Hildreth, Simon Bill, Jacob P Sunnerberg, Megan A Clark, Lesley Jarvis and 4 more

Abstract read
In one paragraph

Article in Medical physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tianyuan DaiThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Austin M SloopThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Andreas SchönfeldSun Nuclear Corp, Melbourne, Florida, USA.
Veronika FlattenSun Nuclear Corp, Melbourne, Florida, USA.
Jakub KozelkaSun Nuclear Corp, Melbourne, Florida, USA.
Jeff HildrethSun Nuclear Corp, Melbourne, Florida, USA.
Simon BillSun Nuclear Corp, Melbourne, Florida, USA.
Jacob P SunnerbergThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Megan A ClarkThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Lesley JarvisDepartment of Medicine, Geisel School of Medicine, Dartmouth College Hanover, Lebanon, New Hampshire, USA.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Petr BruzaThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
David J GladstoneThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Rongxiao ZhangThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Optimization of MeV FLASH radiotherapy for normal tissue preservationU01CA260446 · NCI · DARTMOUTH COLLEGE · PI David J. Gladstone, Jack Hoopes · 2022 to 2026
$3.1M
Novel Optimization Methods and Treatment Planning System for Clinically-Deliverable Truly-Hybrid Proton-Photon RadiotherapyR37CA250921 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Hao Gao · 2021 to 2026
$2.2M
Ultra-fast imaging for the safe delivery of electron FLASH radiation therapyR44CA268466 · NCI · DOSEOPTICS, LLC · PI BRUZA, PETR · 2022 to 2023
$2.0M
Simultaneous dose and dose rate optimization for clinical FLASH proton radiotherapyR01CA261964 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GAO, HAO · 2022 to 2025
$2.0M
Training in Surgical InnovationT32EB021966 · NIBIB · DARTMOUTH COLLEGE · PI Eric R Fossum, Sohail K Mirza · 2017 to 2026
$1.7M
Treatment Planning System for Electron FLASH radiation therapyR21CA277420 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZHANG, RONGXIAO · 2024 to 2025
$438k
National Natural Science Foundation of China ZR2021QA099NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA261964NCI NIH HHS R21 CA277420NCI NIH HHS R37 CA250921NCI NIH HHS R44 CA268466NCI NIH HHS U01 CA260446NIBIB NIH HHS T32 EB021966Norris Cotton Cancer Center and Thayer School of Engineering through the shared irradiation service and from National Cancer Institute research 12105160Shandong Provincial Natural Science Foundation 1R21CA277420-01A1
6 · The paper itself

Abstract

backgroundUltra-high-dose-rate (UHDR) electron beams have been commonly utilized in FLASH studies and the translation of FLASH Radiotherapy (RT) to the clinic. The EDGE diode detector has potential use for UHDR dosimetry albeit with a beam energy dependency observed. PURPOSE: The purpose is to present the electron beam response for an EDGE detector in dependence on beam energy, to characterize the EDGE detector's response under UHDR conditions, and to validate correction factors derived from the first detailed Monte Carlo model of the EDGE diode against measurements, particularly under UHDR conditions.

methodsPercentage depth doses (PDDs) for the UHDR Mobetron were measured with both EDGE detectors and films. A detailed Monte Carlo (MC) model of the EDGE detector has been configured according to the blueprint provided by the manufacturer under an NDA agreement. Water/silicon dose ratios of EDGE detector for a series of mono-energetic electron beams have been calculated. The dependence of the water/silicon dose ratio on depth for a FLASH relevant electron beam was also studied. An analytical approach for the correction of PDD measured with EDGE detectors was established.

resultsWater/silicon dose ratio decreased with decreasing electron beam energy. For the Mobetron 9 MeV UHDR electron beam, the ratio decreased from 1.09 to 1.03 in the build-up region, maintained in range of 0.98-1.02 at the fall-off region and raised to a plateau in value of 1.08 at the tail. By applying the corrections, good agreement between the PDDs measured by the EDGE detector and those measured with film was achieved.

conclusionsElectron beam response of an UHDR capable EDGE detector was derived from first principles utilizing a sophisticated MC model. An analytical approach was validated for the PDDs of UHDR electron beams. The results demonstrated the capability of EDGE detector in measuring PDDs of UHDR electron beams.

Indexed as

ElectronsMonte Carlo MethodRadiation DosageRadiation DosimetersRadiometrydiodeEDGEelectronFLASHMonte Carloultra‐high dose rate

Identifiers

PMID38762909
PMCPMC11752437

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.