Evidence map›Paper›PMID 38762843›Full record

SynthesisSurgical and radiologic anatomy : SRA2024

Anatomy of vertebral artery hypoplasia and its relationship with clinical implications: a systematic review and meta-analysis of prevalence.

Juan José Valenzuela-Fuenzalida, Constanza Pamela Rojas-Navia, Amanda Paz Quirós-Clavero, Juan Sanchis-Gimeno, Macarena Rodriguez-Luengo, Pablo Nova-Baeza, Mathias Orellana-Donoso, Álvaro Becerra Farfán, Alejandro Bruna-Mejias, Walter Sepúlveda-Loyola and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Surgical and radiologic anatomy : SRA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juan José Valenzuela-FuenzalidaDepartment of Morphology and Function, Faculty of Health and Social Sciences, Universidad de Las Américas, 8370040, Santiago, Chile. Juan.kine.2015@gmail.com.
Constanza Pamela Rojas-NaviaDepartamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, 8370146, Santiago, Chile.
Amanda Paz Quirós-ClaveroDepartamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, 8370146, Santiago, Chile.
Juan Sanchis-GimenoGIAVAL Research Group, Department of Anatomy and Human Embryology, Faculty of Medicine, University of Valencia, 46001, Valencia, Spain.
Macarena Rodriguez-LuengoDepartamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, 8370146, Santiago, Chile.
Pablo Nova-BaezaDepartamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, 8370146, Santiago, Chile.
Mathias Orellana-DonosoEscuela de Medicina, Universidad Finis Terrae, 7501015, Santiago, Chile.
Álvaro Becerra FarfánDepartamento de Ciencias Química y Biológicas, Facultad de Ciencias de La Salud, Universidad Bernardo O'Higgins, 8370993, Santiago, Chile.
Alejandro Bruna-MejiasDepartamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, 8370146, Santiago, Chile.
Walter Sepúlveda-LoyolaFaculty of Health and Social Sciences, Universidad de Las Américas, 8370040, Santiago, Chile.
Joe IwanagaDepartment of Oral and Maxillofacial Anatomy, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe vertebral artery (VA) is a vital branch of the subclavian artery, coursing through the transverse foramina of the cervical vertebrae, and playing a crucial role in irrigating the posterior region of the arterial cerebral circle, also known as the Polygon of Willis. Among the various possible alterations that can affect the VA, vertebral artery hypoplasia (HAV) emerges as a significant variant. This study aims to discern the anatomical features of HAV and its correlation with the clinical conditions of the posterior cerebral circulation.

methodsThe databases Medline, Scopus, Web of Science, Google Scholar, CINAHL, and LILACS were searched until January 2024. Two authors independently performed the search, study selection, and data extraction. Methodological quality was evaluated with an assurance tool for anatomical studies (AQUA). Pooled prevalence was estimated using a random effects model.

resultsA total of 24 studies met the established selection criteria, with a total of 8847 subjects. In this study, 6 articles were included for the meta-analysis with a total of subjects. The average prevalence of VAH reported in each study was 11% (95% CI 10-12%); the studies had a heterogeneity of 41% based on the funnel plot and a low risk of bias.

conclusionThe prevalence of VAH is low, but in the presence of this condition, the changes are mainly in diameter rather than morphological. If it is present, some clinical safeguards must be taken to avoid complications such as stroke.

Indexed as

Anatomic VariationVertebral ArteryHumansPrevalenceClinical anatomyEncephalic irrigationVariation anatomicalVascularization brainVertebral arteryVertebral artery hypoplasia

Identifiers

PMID38762843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.