Evidence map›Paper›PMID 38762839›Full record

SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2024

Extra-skeletal intracranial mesenchymal chondrosarcoma: systematic-literature review.

Sivaraman Kumarasamy, Kanwaljeet Garg, Ajay Garg, M C Sharma, Manmohanjit Singh, Poodipedi Sarat Chandra, Shashank Sharad Kale

Abstract readCase ReportsSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Maxillary mesenchymal chondrosarcoma harboringFrontiers in pediatrics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sivaraman KumarasamyDepartment of Neurosurgery, All India Institute of Medical Sciences, Room No 720, CNC, New Delhi, India.
Kanwaljeet GargDepartment of Neurosurgery, All India Institute of Medical Sciences, Room No 720, CNC, New Delhi, India. kanwaljeet84@gmail.com.
Ajay GargDepartment of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India.
M C SharmaDepartment of Neuropathology, All India Institute of Medical Sciences, New Delhi, India.
Manmohanjit SinghDepartment of Neurosurgery, All India Institute of Medical Sciences, Room No 720, CNC, New Delhi, India.
Poodipedi Sarat ChandraDepartment of Neurosurgery, All India Institute of Medical Sciences, Room No 720, CNC, New Delhi, India.
Shashank Sharad KaleDepartment of Neurosurgery, All India Institute of Medical Sciences, Room No 720, CNC, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntracranial mesenchymal chondrosarcoma (IMC) is a rare malignant tumor in pediatric population. IMC can present as extra- or intra-axial lesion in pediatric patients, though the former is commoner causing raised intracranial pressure (ICP). Radiological diagnosis is a challenge in these cases, as is it difficult to differentiate these from other extra-axial neoplasms due to the wide differential diagnosis in pediatric population. We aim to systematically review the literature and present a rare case of extraskeletal intracranial mesenchymal chondrosarcoma treated with safe maximal resection.

methodsA systematic review of literature was conducted in accordance with PRISMA guidelines. PubMed and Scopus databases were queried using the search terms, "primary intracranial chondrosarcoma", "extraskeletal mesenchymal chondrosarcoma", "mesenchymal chondrosarcoma" and "pediatric". Presentation, surgical management and outcome of a 15-year-old male with an extraskeletal IMC are also described.

resultsThe search yielded 25 articles which met the inclusion criteria. These published records consisted of 33 IMC cases with mean age at presentation of 9.81 ± 5.2 years (range 2 months to 18 years). Frontal region was the commonest locations (11, 33.3%). Most common presentation was headache (14, 42.4%). All patients underwent surgical intervention: gross total resection (20, 60.6%), subtotal resection (9, 27.3%) and no extent mentioned (4, 12.1%). No adjuvant therapy was received in 15 patients (45.5%). On latest follow-up, 11 patients (33.3%) are on remission, 5 patients (15.2%) are symptom free, 3 patients (9.1%) had recurrence, 2 patients (6.1%) had metastasis and 9 patients (27.3%) expired.

conclusionIMC is a rare entity in pediatric population with imaging findings which are non-characteristic leading to its diagnostic challenge. It can masquerade as other extra-axial intracranial neoplasm (meningioma or hemangiopericytoma). Combination of clinico-radiological and pathological examination can help in accurate diagnosis.  Safe Maximal resection followed by radiotherapy is the preferred treatment strategy.

Indexed as

Brain NeoplasmsChondrosarcoma, MesenchymalAdolescentChildChild, PreschoolFemaleHumansInfantMaleExtra-axialIntracranial mesenchymal chondrosarcomaPediatric

Identifiers

PMID38762839

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.