ArticleMolecular psychiatry2024
Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo.
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Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20citing papers in PubMed, 1 pooled it
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammatory cytokine alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and network meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Rannasangpei and its constituent crocin-1 ameliorate valproic acid-induced autism-like behaviors accompanied by reduced oxidative stress and neuroinflammation.Translational psychiatry · 2026Article
- Exploring the Molecular Mechanisms of Autism Induced by Early Childhood Exposure to Bisphenol A Based on Network Toxicology and Molecular Docking.International journal of molecular sciences · 2026Article
- CaMKIIα inhibition facilitates functional recovery after preterm hypoxic-ischemic brain injury by disrupting microglial GPNMB signaling.Translational pediatrics · 2026Article
- Haplotype-resolved methylomes reveal parent-of-origin DNA methylation imbalance in autism spectrum disorder.Science advances · 2026Article
- Investigating brain-derived neurotrophic factor (BDNF) changes in three main rodent models of autism spectrum disorder (ASD): a systematic review.Neurotoxicity research · 2026Review
- proBDNF-SorCS2 Axis Suppresses Osteogenesis and Augments Inflammation of Human Periodontal Ligament Stem Cells in Inflammatory Conditions.International dental journal · 2026Article
- Perinatal hyperandrogenization and immune activation in rodents model subtypes of autism.Translational psychiatry · 2026Article
- Decoding BDNF in neurodevelopmental, neurodegenerative, and neurological disorders: mechanisms and therapeutic perspectives.Molecular biology reports · 2026Review
- Fetal Neuronal Vesicles in the Assessment of Perinatal Brain Dysfunction and Late-Onset Growth Restriction: A Pilot Study.International journal of molecular sciences · 2026Article
- Deletion of Glutamate Delta 1 Receptor Leads to Heterogeneous Transcription and Synaptic Gene Alterations Across Brain Regions.International journal of molecular sciences · 2025Article
- Cntn4 Gene Deficiency Promotes Autism-Like Phenotypes Associated with Gut Microbiota Perturbations and Gut-Brain Axis Metabolomic Alterations in Mice.Molecular neurobiology · 2025Article
- Serum Proteomics Reveals Diagnostic Biomarkers and Molecular Pathways in Cerebral Palsy.Nature communications · 2025Article
- A comparison of commercial assays quantifying mature brain-derived neurotrophic factor (mBDNF) and its precursor (pro-BDNF) in human serum.Scientific reports · 2025Article
- Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective.International journal of molecular sciences · 2025Review
- Neuroplasticity-Based Approaches to Sensory Processing Alterations in Autism Spectrum Disorder.International journal of molecular sciences · 2025Review
- Behavioral Abnormalities, Cognitive Impairments, Synaptic Deficits, and Gene Replacement Therapy in a CRISPR Engineered Rat Model of 5p15.2 Deletion Associated With Cri du Chat Syndrome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion-Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway.Brain and behavior · 2025Article
- Brain-derived neurotrophic factor levels and oxidative stress in autism: evidence from children and a mouse model.Journal of psychiatry & neuroscience : JPNArticle
- Exercise modulation of BDNF/TrkB signaling in Parkinson's disease: an evidence-calibrated review of neuroprotective mechanisms, biomarker limitations, and translational gaps.Frontiers in neurologyReview
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Authors and funding
15 authors.
Feng Yang *China National Clinical Research Center for Neurological Diseases, Basic and Translational Medicine Center, Beijing Tiantan Hospital, Capital Medical University, 100070, Beijing, China.
He You *Advanced Innovation Center for Human Brain Protection, Capital Medical University, 100070, Beijing, China.ORCID 0009-0000-4579-720X
Toshiyuki Mizui *Core Research for Evolutional Science and Technology (CREST), Kawaguchi, 332-0012, Japan.
Yasuyuki IshikawaDepartment of Systems Life Engineering, Maebashi Institute of Technology, Maebashi, 371-0816, Japan.ORCID 0000-0002-8229-0106
Keizo TakaoCore Research for Evolutional Science and Technology (CREST), Kawaguchi, 332-0012, Japan.
Tsuyoshi MiyakawaCore Research for Evolutional Science and Technology (CREST), Kawaguchi, 332-0012, Japan.ORCID 0000-0003-0137-8200
Xiaofei LiChina National Clinical Research Center for Neurological Diseases, Basic and Translational Medicine Center, Beijing Tiantan Hospital, Capital Medical University, 100070, Beijing, China.
Ting BaiCentre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Kun XiaCentre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Lingling ZhangHenan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Dizhou PangCenter for Child Behavioral Development, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yiran XuHenan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Changlian ZhuHenan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.ORCID 0000-0002-5029-6730
Masami KojimaCore Research for Evolutional Science and Technology (CREST), Kawaguchi, 332-0012, Japan. masamikojima@neptune.kanazawa-it.ac.jp.
Bai LuAdvanced Innovation Center for Human Brain Protection, Capital Medical University, 100070, Beijing, China. bai_lu@mail.tsinghua.edu.cn.ORCID 0000-0001-5418-9759
Funding
Ministry of Education, Culture, Sports, Science and Technology (MEXT) 22K06448National Natural Science Foundation of China (National Science Foundation of China) 31730034National Natural Science Foundation of China (National Science Foundation of China) 81501105National Natural Science Foundation of China (National Science Foundation of China) 81861138013Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) IS23097Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) L222077
Abstract
Autism Spectrum Disorders (ASD) comprise a range of early age-onset neurodevelopment disorders with genetic heterogeneity. Most ASD related genes are involved in synaptic function, which is regulated by mature brain-derived neurotrophic factor (mBDNF) and its precursor proBDNF in a diametrically opposite manner: proBDNF inhibits while mBDNF potentiates synapses. Here we generated a knock-in mouse line (BDNF
Indexed as
Autism Spectrum DisorderBrain-Derived Neurotrophic FactorDisease Models, AnimalHippocampusPhenotypeProtein PrecursorsAnimalsBrainCase-Control StudiesChildFemaleGene Knock-In TechniquesHumansMaleMiceMice, Inbred C57BLBdnf protein, mouseBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factor precursorProtein Precursors
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PMID
38762692What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.