ArticleInternational journal of obesity (2005)2024
Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study.
Article in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Metabolic obesity phenotypic stability, dynamic transformation and risk of hypertension: a 10-year prospective cohort study in southwest China.International journal of obesity (2005) · 2026Article
- Chronic High-Fat Diet Does Not Alter Overall Cancer Incidence in Trp53R270H/+ Mice.Cancer research communications · 2026Article
- Metabolically "healthy" obesity in postmenopausal women: Unmasking the cardiovascular risk.World journal of cardiology · 2025Article
- Different Metabolic Phenotypes of Obesity and 2 Decades Risk of Cardio-Renal-Metabolic Multimorbidity: Tehran Lipid and Glucose Study.Journal of the American Heart Association · 2025Article
- Association between Metabolic Syndrome and Cardiovascular Events in a Japanese Population with and without Obesity: The Shizuoka Kokuho Database Study.Journal of atherosclerosis and thrombosis · 2025Article
- Hepatic fat and dietary intake as determinants of metabolic health in obese adolescents: a cross-sectional MRI study.Frontiers in nutrition · 2025Article
- The Association of Weight Categories in Adolescence with Cardiovascular Morbidity in Young Adult Israeli Arabs-A Nationwide Study.Journal of clinical medicine · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy obesity by comparing clinical profile-matched metabolically healthy obesity and non-obesity groups.
methodsWe analyzed a health insurance dataset with annual health checkup data from Japan. The analyzed data included 168,699 individuals aged <65 years. Obesity was defined as ≥25 kg/m
resultsThe stroke (obesity: 9.2 per 10,000 person-years; non-obesity: 10.5; log-rank test p = 0.595), myocardial infarction (obesity: 3.7; non-obesity: 3.1; p = 0.613), and all-cause mortality (obesity: 26.6; non-obesity: 23.2; p = 0.304) incidence rates did not differ significantly between the metabolically healthy obesity and non-obesity groups, even when the abdominal obesity was considered in the analysis. The lack of association was also observed in the comparison between the metabolically unhealthy obesity and non-obesity groups (n = 10,965 each). The population with metabolically healthy obesity reported negligibly worse metabolic profiles than the population with non-obesity at the 5.6-year follow-up.
conclusionObesity, when accompanied by a healthy metabolic profile, did not increase the risk of cardiovascular outcomes and all-cause mortality.
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