ArticleScientific reports2024
New insights into the effects of type and timing of childhood maltreatment on brain morphometry.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Associations of childhood maltreatment types and timing with oxidative stress in formerly out-of-home placed young adults.European journal of psychotraumatology · 2026Article
- Differential effects of childhood maltreatment types and timing on psychopathology in formerly out-of-home placed young adults.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The moderating effect of lifetime physical activity on brain alterations related to adverse childhood experiences.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Childhood trauma and inflammatory biomarker effects on cortical thinning in schizophrenia spectrum disorders.Brain, behavior, & immunity - health · 2025Article
- Child Maltreatment Characteristics and Adult Physical Multimorbidity in Germany.JAMA network open · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Childhood maltreatment (CM) is known to influence brain development. To obtain a better understanding of related brain alterations, recent research has focused on the influence of the type and timing of CM. We aimed to investigate the association between type and timing of CM and local brain volume. Anatomical magnetic resonance images were collected from 93 participants (79 female/14 male) with a history of CM. CM history was assessed with the German Interview Version of the "Maltreatment and Abuse Chronology of Exposure" scale, "KERF-40 + ". Random forest regressions were performed to assess the impact of CM characteristics on the volume of amygdala, hippocampus and anterior cingulate cortex (ACC). The volume of the left ACC was predicted by neglect at age 3 and 4 and abuse at age 16 in a model including both type and timing of CM. For the right ACC, overall CM severity and duration had the greatest impact on volumetric alterations. Our data point to an influence of CM timing on left ACC volume, which was most pronounced in early childhood and in adolescence. We were not able to replicate previously reported effects of maltreatment type and timing on amygdala and hippocampal volume.
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