Evidence map›Paper›PMID 38762542›Full record

ArticleTrials2024

ZOom Delivered Intervention Against Cognitive decline (ZODIAC) COVID-19 pandemic adaptations to the Post-Ischaemic Stroke Cardiovascular Exercise Study (PISCES): protocol for a randomised controlled trial of remotely delivered fitness training for brain health.

Amy Brodtmann, Alex Billett, Rachael Telfer, Kim Adkins, Laura White, Laura J E McCambridge, Louise M Burrell, Vincent Thijs, Sharon Kramer, Emilio Werden and 7 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Precision Surgery for Glioblastomas.Journal of personalized medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Amy BrodtmannDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. amy.brodtmann@monash.edu.ORCID http://orcid.org/0000-0001-9466-2862
Alex BillettDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Rachael TelferDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Kim AdkinsDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Laura WhiteDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Laura J E McCambridgeThe Florey, Melbourne, VIC, Australia.
Louise M BurrellDepartment of Medicine, University of Melbourne, Melbourne, VIC, Australia.
Vincent ThijsThe Florey, Melbourne, VIC, Australia.
Sharon KramerDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Emilio WerdenThe Florey, Melbourne, VIC, Australia.
Barbara R CardosoDepartment of Nutrition, Dietetics and Food, Monash University, Melbourne, VIC, Australia.
Matthew PaseTurner Institute, Monash University, Melbourne, VIC, Australia.
Stanley Hughwa HungDepartment of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Leonid ChurilovDepartment of Medicine, University of Melbourne, Melbourne, VIC, Australia.
Julie BernhardtThe Florey, Melbourne, VIC, Australia.
Kathryn HaywardThe Florey, Melbourne, VIC, Australia.
Liam JohnsonThe Florey, Melbourne, VIC, Australia.

Funding

National Health and Medical Research Council RART 93889866National Heart Foundation of Australia 100784National Institute for Dementia Research GNT1171890Wellcome Trust 104748
6 · The paper itself

Abstract

backgroundStroke increases subsequent dementia risk yet there are no specific post-stroke therapies to protect cognition. Cardiorespiratory exercise is recommended for secondary prevention of stroke and may be neuroprotective. The Post Ischaemic Stroke Cardiovascular Exercise Study (PISCES) aims to reduce post-stroke secondary neurodegeneration and cognitive decline. During the pandemic, we pivoted to a ZOom Delivered Intervention Against Cognitive decline (ZODIAC) protocol, reducing pandemic-amplified barriers to exercise.

methodsWe present pandemic adaptions for a multicentre phase IIb assessor-blinded randomised controlled trial of ischaemic stroke survivors testing the efficacy and feasibility of an 8-week home-based exercise intervention delivered at 2 months post-stroke. We compare cardiorespiratory exercise (intervention arm) versus balance and stretching (active control arm). Participants are assessed with magnetic resonance imaging (MRI), fitness, blood, microbiome, and neuropsychological tests at three study visits: before and after the exercise intervention and at 12 months. Modifications to the original protocol include pre-exercise safety home visits, commercial delivery of exercise equipment to facilitate assessor blinding, and reconsideration of statistical plan to allow pooling of the studies. We have reduced in-person study visits from 27 to 3. Primary outcome remains between-group (intervention versus control) difference in brain volume change; secondary outcome is between-group difference in global cognitive ability to allow remote administration of a validated cognitive scale. DISCUSSION: Remotely delivered exercise interventions reduce participant burden and may reduce barriers to recruitment. A decrease in the number of in-person study visits can be supported by greater information capture via self-reported questionnaires and phone surveys.

trial registrationProspectively ACTRN12616000942459. Registered on July 2016.

Indexed as

Cognitive DysfunctionCOVID-19Exercise TherapyStroke RehabilitationCardiorespiratory FitnessClinical Trials, Phase II as TopicCognitionHumansIschemic StrokeMagnetic Resonance ImagingMulticenter Studies as TopicRandomized Controlled Trials as TopicSARS-CoV-2Treatment OutcomeBrain volumeCognitionDementiaExercise trainingIschaemic strokePhysical activityTelerehabilitation

Identifiers

PMID38762542
PMCPMC11102145

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.