ReviewCell death discovery2024
Sperm freezing damage: the role of regulated cell death.
Review in Cell death discovery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06560216 (Effects of Supplementation of Cryopreservation Medium With Apigenin on Post-thaw Human Sperm), which is not on this map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Supplementation of Cryopreservation Medium With Apigenin on Post-thaw Human Sperm
Who cites it
49 citing papers in PubMed.
- Platelet-Derived Growth Factor Receptor Alpha in Male Reproductive Health and Oxidative Stress: Stromal Homeostasis, Injury, and Research Perspectives.Antioxidants (Basel, Switzerland) · 2026Review
- Proteomic Profiling of Cryopreservation-Induced Alterations in Rhesus Macaque Sperm.Andrology · 2026Article
- Optimize human sperm cryopreservation: influence of vial sealing methods and automated freezing protocols on preserved sperm quality.Translational andrology and urology · 2026Article
- Article
- Post-thaw quality of donkey (Equus asinus) spermatozoa exposed to different concentrations of curcumin with respect to oxidative status and nitric oxide.Veterinary research communications · 2026Review
- Dose-Dependent Effects of Protocatechuic Acid on Motility, Redox Balance, and DNA Integrity of Frozen-Thawed Ram Spermatozoa.International journal of molecular sciences · 2026Article
- Innovative nanotechnology approach using salicylic acid loaded chitosan nanoparticles to improve post-thaw sperm function, reduce apoptosis, and preserve ultrastructure in rams.Tropical animal health and production · 2026Article
- Current Advances in Cetacean Semen Cryopreservation and Their Application to Yangtze Finless Porpoise Conservation.Animals : an open access journal from MDPI · 2026Review
- Effects of Kaempferol Supplementation on the Cryopreservation Quality of Semen from Yuansheng Aite Dairy Rams.Antioxidants (Basel, Switzerland) · 2026Article
- The Impacts of Mitoquinone Supplementation on Oxidative Status and Cryo-Survival of Cryopreserved Male Donkey (Veterinary sciences · 2026Article
- Oxidative Stress-Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis.Journal of cellular and molecular medicine · 2026Review
- Current status and advances in bovine semen production technologies for artificial insemination in Japan.The Journal of reproduction and development · 2026Review
- Mapping the Scientometric Landscape of Andrology: Trends, Gaps, and Future Directions in Male Reproductive Health: A Scoping Review.The world journal of men's health · 2026Article
- L-Selenomethionine Alleviates Cryo-Induced Ferroptosis Through the NRF2-SLC7A11-GPX4 Pathway, Improving Post-Thaw In Vitro Quality of Dairy Goat Spermatozoa.Antioxidants (Basel, Switzerland) · 2026Article
- The Effects of Graphene Oxide Nanoparticles on the Cryopreservation of Angora Buck Sperm.Molecules (Basel, Switzerland) · 2026Article
- Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.Scientific reports · 2026Article
- Protective Effect ofAntioxidants (Basel, Switzerland) · 2026Article
- Deep learning-enabled morphology analysis of bovine sperm for label-free imaging flow cytometry.Frontiers in veterinary science · 2026Article
- Editorial: Innovative strategies for improving sperm lifespan during storage.Frontiers in veterinary science · 2026Article
- Unveiling novel insights into the role and characteristics of sperm heat shock protein 70 in indigenous Donggala bulls: implications for molecular-based motility markers.Archives animal breeding · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substantial progress in research on sperm cryopreservation has occurred since the twentieth century, especially focusing on improving sperm freezing procedures and optimizing semen extenders. However, the cellular biological mechanisms of sperm freezing damage are still unclear, which greatly restricts the promotion and development of sperm cryopreservation. An essential component of sperm freezing damage is the occurrence of cell death. Considering the existence of multiple types of cell death pathways, this review discusses connections between characteristics of regulated cell death (e.g., apoptosis and ferroptosis), and accidental cell death (e.g., intracellular ice crystals) with sperm freezing damage and explores possible future research directions in this field.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.