ArticleNature communications2024
Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- Gut microbiota and immunometabolism in obesity.Gut microbes · 2026Review
- Gut-derived bacterial extracellular vesicles: the microbial dark matter contributing to host inflammation and cardiometabolic disease.Gut microbes · 2026Review
- Lachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.Comprehensive reviews in food science and food safety · 2026Review
- Network-based prioritization of sepsis-associated metabolites and in vivo validation of diosmetin in sepsis-associated acute kidney injury.Molecular biology reports · 2026Article
- Causal relationship between dietary habits and low hand grip strength: A Mendelian randomization study.Medicine · 2026Article
- Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review).Molecular medicine reports · 2026Review
- Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications.Molecular medicine (Cambridge, Mass.) · 2026Review
- Comorbidity Between Mood Disorders and Chronic Somatic Diseases, With a Focus on Cardiometabolic Disease, and Its Mechanistic Crosstalk.Depression and anxiety · 2026Review
- Capsaicin attenuates high-fat diet-induced impairment of B-cell immunity.SAGE open medicine · 2026Article
- Acute Sleep Deprivation and the Autoimmune TLR-BANK1 Pathway: Interplay with Gender and Emotional State.International journal of molecular sciences · 2025Article
- L-theanine-targeted prefrontal cortex improves CUMS-induced depression via the gut-short-chain fatty acids-brain axis.NPJ science of food · 2025Article
- 4'-hydroxychalcone nanofiber hydrogel dressing promotes diabetic chronic wound healing by regulating macrophage polarization via the TLR/IL-17/TNF signaling pathway.Materials today. Bio · 2025Article
- Toll-Like Receptors in the Immunotherapy Era: Dual-Edged Swords of Tumor Immunity and Clinical Translation.MedComm · 2025Review
- Identifying propionate metabolism-related genes as biomarkers of sepsis development and therapeutic targets.Scientific reports · 2025Article
- B cells in non-lymphoid tissues.Nature reviews. Immunology · 2025Review
- Review
- Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review.International journal of molecular sciences · 2025Review
- DNA sensors in metabolic and cardiovascular diseases: Molecular mechanisms and therapeutic prospects.Immunological reviews · 2025Review
- Association of systemic immune-inflammation index with body mass index, waist circumference and prevalence of obesity in US adults.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Pai Wang *Department of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.ORCID http://orcid.org/0000-0002-6024-7588
Xin Yang *Section of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Luyao ZhangDepartment of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Sha ShaSection of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Juan HuangSection of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Jian PengSection of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Jianlei GuDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
James Alexander PearsonSection of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2867-2269
Youjia HuSection of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Hongyu ZhaoDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1195-9607
F Susan WongDivision of Infection and Immunity, School of Medicine and Systems Immunity University Research Institute, Cardiff University, Cardiff, UK.
Quan WangDepartment of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China. wquan@jlu.edu.cn.
Li WenSection of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA. li.wen@yale.edu.ORCID http://orcid.org/0000-0002-8805-2934
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0MAntibody and gut bacteria in obesity and T2DR01DK126809 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2021 to 2024
$1.8MIdentifying immunoregulatory gut bacteria in type 1 diabetes and autoimmunityR01DK130318 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2022 to 2025
$1.6MInvestigating the early development of the immune system and islet autoimmunity later in lifeR01HD097808 · NICHD · YALE UNIVERSITY · PI WEN, LI · 2019 to 2021
$1.3MDiabetes Action Research and Education Foundation (Diabetes Action) HD097808Medical Research Council MR/K021141/1Medical Research Council MR/T010525/1NCATS NIH HHS UL1 TR001863NICHD NIH HHS R01 HD097808NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK126809NIDDK NIH HHS R01 DK130318
Abstract
Toll-like receptor 9 (TLR9) recognizes bacterial, viral and self DNA and play an important role in immunity and inflammation. However, the role of TLR9 in obesity is less well-studied. Here, we generate B-cell-specific Tlr9-deficient (Tlr9
Indexed as
B-LymphocytesDiet, High-FatDysbiosisGastrointestinal MicrobiomeInflammationInterleukin-10Mice, KnockoutObesityToll-Like Receptor 9AnimalsDisease Models, AnimalInterferon Regulatory Factor-4Interferon Regulatory FactorsMaleMiceMice, Inbred C57BLIL10 protein, mouseInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-10Tlr9 protein, mouseToll-Like Receptor 9
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.