Evidence map›Paper›PMID 38762471›Full record

ArticleLipids in health and disease2024

The association between remnant cholesterol and bone mineral density in US adults: the National Health and Nutrition Examination Survey (NHANES) 2013-2018.

Peilun Xiao, Zhihang Wang, Zeyao Lu, Shijia Liu, Chongjun Huang, Ying Xu, Ye Tian

Abstract read
In one paragraph

Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Association between remnant cholesterol level and gout in US adults.The Journal of international medical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peilun XiaoDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Zhihang WangDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Zeyao LuDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Shijia LiuDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Chongjun HuangDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Ying XuDepartment of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China. xuy5@sj-hospital.org.
Ye TianDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China. tiany3@sj-hospital.org.ORCID http://orcid.org/0000-0003-3931-6427

Funding

National Natural Science Foundation of China 82271294Natural Science Foundation of Liaoning Province 2021-MS-201the Applied Basic Research Program of Liaoning Province 2022JH2/101500050the Basic Scientific Research Projects of Liaoning Provincial Department of Education LJKMZ20221164
6 · The paper itself

Abstract

backgroundPrevious evidence showed a possible link of dyslipidemia with bone health. Nevertheless, the correlation of remnant cholesterol (RC) with bone mineral density (BMD) has yet to be well investigated. This study investigated the association of RC with total spine BMD in general Americans.

methodsThis study explored the relationship of RC with total spine BMD in subjects aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) 2013-2018. After adjusting for covariates, multivariate linear regression and stratified analyses were conducted to determine the correlation of serum RC with total spine BMD in adult Americans. Restricted cubic spline (RCS) was applied to examine the nonlinear association of serum RC with total spine BMD.

resultsThis study included 3815 individuals ≥ 20 years old, 1905 (49.93%) of whom were men and 1910 (50.07%) of whom were women. After adjusting for all covariates, the results showed a negative relationship of serum RC with total spine BMD (β= -0.024, 95% CI: -0.039, -0.010). The interaction tests of age, sex, race, and BMI showed no statistically significant effects on the association. The RCS also indicated a negative linear correlation of serum RC with total spine BMD (nonlinear P = 0.068, overall P < 0.001). Moreover, RC had a stronger effect on total spine BMD than total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C).

conclusionsThis study found that serum RC was negatively related to total spine BMD in U.S. adults. These findings emphasized the important role of RC in bone health in American adults.

Indexed as

Bone DensityCholesterolNutrition SurveysAdultAgedFemaleHumansLinear ModelsMaleMiddle AgedSpineUnited StatesYoung AdultCholesterolAmericansBone mineral densityNHANESRemnant cholesterol

Identifiers

PMID38762471
PMCPMC11102129

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.