Evidence map›Paper›PMID 38762372›Full record

ArticleTrends in parasitology2024

To kill a tachyzoite: assault and battery.

Azadeh Nasuhidehnavi, George S Yap

Abstract readComment
In one paragraph

Article in Trends in parasitology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Azadeh NasuhidehnaviCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
George S YapCenter for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, NJ, USA. Electronic address: yapgs@njms.rutgers.edu.

Funding

GDF-15 as a mediator of immune-regulated sickness response during infectionR21AI171670 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YAP, GEORGE S. · 2023 to 2024
$417k
NIAID NIH HHS R21 AI171670
6 · The paper itself

Abstract

Polymeric guanylate-binding proteins (GBPs) physically dismember the vacuole membrane formed by Toxoplasma gondii while nitric oxide (NO) poisons and inhibits parasite replication within interferon (IFN)-γ activated macrophages. Zhao et al. report a novel mechanism for synergy between these classical microbicidal and microbistatic effectors in cell-autonomous immunity to the intracellular parasites.

Indexed as

ToxoplasmaAnimalsGTP-Binding ProteinsHumansMacrophagesNitric OxideGTP-Binding ProteinsNitric Oxidecell autonomous immunityGBPiNOSnitrosylation

Identifiers

PMID38762372
PMCPMC11156527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.