Evidence map›Paper›PMID 38762187›Full record

Trial reportThe American journal of clinical nutrition2024

The effects of whey, pea, and collagen protein supplementation beyond the recommended dietary allowance on integrated myofibrillar protein synthetic rates in older males: a randomized controlled trial.

James McKendry, Caroline V Lowisz, Arraksana Nanthakumar, Meaghan MacDonald, Changhyun Lim, Brad S Currier, Stuart M Phillips

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04026607 nacompletednot on this map

Efficacy of Higher Versus Lower Quality Protein Supplementation to Support Increased Muscle Protein Synthesis in Older Men

TypeinterventionalSponsorMcMaster UniversityRan2019 to 2023Enrolled45ConditionsSarcopeniaArmsProtein Supplementation
NCT07356440 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Consumption of Vegetable Protein-enriched Biscuits and Vitamin D Supplementation on the Progression of Sarcopenia in Elderly Subjects

TypeinterventionalSponsorUniversity of UdineRan2025 to 2026Enrolled74ConditionsSarcopenia in Elderly, Sarcopenia, Nutritional Intervention, Microbiome AnalysisArmsVitamin D3 supplement, Protein-enriched biscuits, Control biscuit, Placebo oil
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James McKendryDepartment of Kinesiology, Exercise Metabolism Research Group, McMaster University, Hamilton, Ontario, Canada.
Caroline V LowiszDepartment of Kinesiology, Exercise Metabolism Research Group, McMaster University, Hamilton, Ontario, Canada.
Arraksana NanthakumarDepartment of Kinesiology, Exercise Metabolism Research Group, McMaster University, Hamilton, Ontario, Canada.
Meaghan MacDonaldDepartment of Kinesiology, Exercise Metabolism Research Group, McMaster University, Hamilton, Ontario, Canada; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Changhyun LimDepartment of Kinesiology, Exercise Metabolism Research Group, McMaster University, Hamilton, Ontario, Canada.
Brad S CurrierDepartment of Kinesiology, Exercise Metabolism Research Group, McMaster University, Hamilton, Ontario, Canada.
Stuart M PhillipsDepartment of Kinesiology, Exercise Metabolism Research Group, McMaster University, Hamilton, Ontario, Canada. Electronic address: phillis@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkeletal muscle mass is determined predominantly by feeding-induced and activity-induced fluctuations in muscle protein synthesis (MPS). Older individuals display a diminished MPS response to protein ingestion, referred to as age-related anabolic resistance, which contributes to the progression of age-related muscle loss known as sarcopenia.

objectivesWe aimed to determine the impact of consuming higher-quality compared with lower-quality protein supplements above the recommended dietary allowance (RDA) on integrated MPS rates. We hypothesized that increasing total protein intake above the RDA, regardless of the source, would support higher integrated rates of myofibrillar protein synthesis.

methodsThirty-one healthy older males (72 ± 4 y) consumed a controlled diet with protein intake set at the RDA: control phase (days 1-7). In a double-blind, randomized controlled fashion, participants were assigned to consume an additional 50 g (2 × 25g) of whey (n = 10), pea (n = 11), or collagen (n = 10) protein each day (25 g at breakfast and lunch) during the supplemental phase (days 8-15). Deuterated water ingestion and muscle biopsies assessed integrated MPS and acute anabolic signaling. Postprandial blood samples were collected to determine feeding-induced aminoacidemia.

resultsIntegrated MPS was increased during supplemental with whey (1.59 ± 0.11 %/d; P < 0.001) and pea (1.59 ± 0.14 %/d; P < 0.001) when compared with RDA (1.46 ± 0.09 %/d for the whey group; 1.46 ± 0.10 %/d for the pea group); however, it remained unchanged with collagen. Supplemental protein was sufficient to overcome anabolic signaling deficits (mTORC1 and rpS6), corroborating the greater postprandial aminoacidemia.

conclusionsOur findings demonstrate that supplemental protein provided at breakfast and lunch over the current RDA enhanced anabolic signaling and integrated MPS in older males; however, the source of additional protein may be an important consideration in overcoming age-related anabolic resistance. This trial was registered clinicaltrials.gov as NCT04026607.

Indexed as

CollagenDietary SupplementsMuscle ProteinsWhey ProteinsAgedDouble-Blind MethodHumansMaleMuscle, SkeletalMyofibrilsPea ProteinsRecommended Dietary AllowancesCollagenMuscle ProteinsPea ProteinsWhey Proteinsagingmuscle anabolismnutrient requirementsplant-based proteinprotein nutritionsarcopeniastable isotope tracers

Identifiers

PMID38762187
PMCPMC11291473

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.