SynthesisInternational urology and nephrology2024
Don't wait any longer, conceive in time: a systematic review and meta-analysis based on semen parameters after varicocelectomy.
Synthesis in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinical Recommendations for the Management of Male Infertility: A Consensus from the Korean Society for Sexual Medicine and Andrology (KSSMA) Clinical Practice Guideline Committee.The world journal of men's health · 2026Review
- Predictive parameters of semen outcome improvement after varicocele treatment by scleroembolization: a retrospective study.Journal of endocrinological investigation · 2026Article
- The Effects of Varicocele Repair on Testicular Sperm Retrieval, Sperm Recovery in the Ejaculate and Clinical Pregnancy Rates in Non-Obstructive Azoospermic Men with Clinical Varicocele: A Systematic Review and Meta-Analysis.The world journal of men's health · 2026Article
- Oxidative Damage, Antioxidant Capacity, and Apoptotic Activation in Varicocele: Biochemical Evidence of Improvement After Surgical Repair.Antioxidants (Basel, Switzerland) · 2026Article
- Impact of varicocoelectomy on male semen parameters: A long-term analysis of sperm quality and outcomes.Andrology · 2026Article
- Epidemiological, Clinical, and Biomarker Profile of Male Infertility in Morocco: A Retrospective Single-Center Study of 1399 Cases.Diseases (Basel, Switzerland) · 2025Article
- Article
- Pathophysiological effects of hypoxia on testis function and spermatogenesis.Nature reviews. Urology · 2025Review
- Assessing the outcomes of subinguinal microsurgical varicocelectomy: pulling technique compared to the conventional method.International urology and nephrology · 2025Article
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5 authors.
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Abstract
backgroundVaricocelectomy was considered to be beneficial to patients with varicocele-related infertility. However, there are only a few researchers who have explored the relationship between better timing and postoperative semen improvement in patients.
methodsWe conducted this meta-analysis by enrolling published prospective studies to find out the best waiting time after varicocelectomy to wait for better improvement of semen quality. An extensive search was conducted in PubMed, Web of Science, and Cochrane Library to identify eligible studies. The included studies were then analyzed comprehensively using STATA software and standardized mean differences (SMDs) and their corresponding 95% confidence intervals were calculated.
resultsOur comprehensive analysis showed that after varicocelectomy, follow-up results within 3 months or longer showed a significant improvement in semen parameters compared to the preoperative period. Notably, no further improvement in semen parameters was observed when the follow-up period reached six months or longer (semen volume: WMD: - 0.07 (- 0.29, 0.16); sperm concentration: WMD: - 1.33 (- 2.33, - 4.99); sperm motility: WMD: 2.31 (- 0.55, 5.18); sperm morphology: WMD: 1.29 (- 0.66, 3.24); sperm total motile count: WMD: 3.95 (- 6.28, 14.19)).
conclusionsThree months after varicocelectomy may be the optimal time for semen parameters compared to six months or even longer, which means it is also the preferable time for conception. However, more well-designed prospective studies are needed in the future to validate our conclusion.
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