ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024
Is there a relationship between the severity of obstructive sleep apnea syndrome and the systemic immune inflammation index?
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The effect of gender on clinical characteristics and diagnostic process of obstructive sleep apnea syndrome.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Obstructive Sleep Apnea and Coronary Artery Disease: An Overlooked Cardiovascular Risk Factor.Biomedicines · 2026Review
- Development and Validation of a Nomogram Incorporating Platelet Distribution Width and the Triglyceride-Glucose Index for Predicting Obstructive Sleep Apnea.Nature and science of sleep · 2026Article
- Impact of C-reactive protein-triglyceride-glucose and systemic immune-inflammation indices on obstructive sleep apnea in older adults with depression.Frontiers in neuroscience · 2026Article
- Combined red blood cell distribution width and neutrophil-to-lymphocyte ratio and risk of composite cardiovascular events in patients with moderate-to-severe obstructive sleep apnea: a prospective cohort study.Frontiers in medicine · 2026Article
- Therapeutic nutrition strategies for the shared pathophysiology of obesity and sleep-disordered breathings.Nutrition journal · 2025Review
- Hematological Biomarkers of the Obstructive Sleep Apnea Syndrome: A Machine Learning-Based Diagnostic and Prognostic Model.Journal of clinical medicine · 2025Article
- Role of hematological parameters and inflammatory indices in determining the severity of obstructive sleep apnea syndrome: reality or myth?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The neutrophil-to-lymphocyte ratio is associated with increased risk of all-cause mortality in obstructive sleep apnea.Scientific reports · 2025Article
- A Possible Missing Link Between Obstructive Sleep Apnea Syndrome (OSA) Associated with Tobacco Use and Inflammation Biomarkers.Healthcare (Basel, Switzerland) · 2025Article
- Systemic immune-inflammation index and systemic inflammation response index: novel hematological predictors of obstructive sleep apnea.Frontiers in neurologyArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimVascular dysfunction, oxidative stress and systemic inflammation are considered responsible for the pathophysiology of Obstructive sleep apnea syndrome (OSAS). It is thought that desaturation due to apnea-hypopnea attacks in OSAS patients activates inflammatory pathways. In this study, we aimed to reveal the relationship between inflammation parameters Systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratios (PLR) severity of OSAS in patients who underwent polysomnography in our hospital's sleep laboratory.
methodsWe grouped our 171 patients who were followed up in our sleep laboratory with the diagnosis of OSAS according to their AHI values. We evaluated the correlation of SII, NLR, and PLR values obtained from the complete blood tests of our patients with OSAS diagnosis and OSAS severity.
resultsThe mean NLR, PLR and SII values of patients with OSAS were statistically significantly higher than those without OSAS (p < 0.05). A positive correlation of 18% was found between the presence of OSAS and the SII value (p = 0.016). No statistically significant difference was found when comparing OSAS severity and NLR, PLR and SII values (p > 0.05).
conclusionWe observed that SII, NLR and PLR parameters, which are rapidly assessable systemic inflammation markers of this process, were independently associated in patients diagnosed with OSAS and that there was no change in SII, NLR, and PLR parameters with OSAS severity.
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