Evidence map›Paper›PMID 38761206›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2024

Prevalence of Age-Related Macular Degeneration in Patients with Chronic Exposure to P2X7R Inhibitors.

Kwang Min Woo, M Abdallah Mahrous, Donald J D'Amico, Szilard Kiss, Kyle D Kovacs

Abstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Role of P2X7R in Retinal Diseases: A Review.Immunity, inflammation and disease · 2025
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kwang Min WooDepartment of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, 11Th Floor, New York, NY, 10021, USA.
M Abdallah MahrousDepartment of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, 11Th Floor, New York, NY, 10021, USA.
Donald J D'AmicoDepartment of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, 11Th Floor, New York, NY, 10021, USA.
Szilard KissDepartment of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, 11Th Floor, New York, NY, 10021, USA.
Kyle D KovacsDepartment of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, 11Th Floor, New York, NY, 10021, USA. kyk9011@med.cornell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeP2X7 receptor (P2X7R) is a purinergic cation channel whose activation has been linked with age-related macular degeneration (ARMD). Several nucleoside reverse transcriptase inhibitors, zidovudine (AZT), lamivudine (3TC) and abacavir (ABC), have been shown to inhibit P2X7R and improve outcomes in animal models of ARMD. Our aim is to investigate the association between chronic AZT, 3TC, and ABC therapy and ARMD in a clinical setting.

methodsThis is a retrospective cohort study comparing 445 patients with HIV and confirmed usage of AZT, 3TC, and ABC against 200 patients with HIV without usage of AZT, 3TC, and ABC and 445 non-HIV infected patients. Fundus examination and spectral domain optical coherence tomography (SD-ODT) were used to measure prevalence of early-intermediate stage ARMD, geographic atrophy, and exudative ARMD.

resultsThere was no statistically significant difference in the prevalence of early-intermediate stage ARMD between the HIV infected patients with a history of AZT, 3TC, and ABC use and the HIV infected patients without AZT, 3TC, and ABC use (p = 0.887). There was also no statistically significant difference in the prevalence of geographical atrophy (p = 0.062) and exudative AMD (p > 0.999) between the HIV infected patients with a history of AZT, 3TC, and ABC use and non-HIV infected patients.

conclusionWe did not find an effect of P2X7R inhibiting antiretrovirals usage on early-intermediate stage ARMD, geographical atrophy, or exudative ARMD. Studies with larger cohort and more rigorous medication history are needed to assess the effects on geographical atrophy or exudative ARMD.

Indexed as

HIV InfectionsReceptors, Purinergic P2X7Tomography, Optical CoherenceAbacavirAgedCyclopropanesDideoxyadenosineDideoxynucleosidesFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansLamivudineMacula LuteaMacular DegenerationAbacavirCyclopropanesDideoxyadenosineDideoxynucleosidesLamivudinePurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7Age-related macular degenerationAntiretroviral agentsChoroidal neovascularizationGeographic atrophyP2X7 receptorRetina

Identifiers

PMID38761206

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.