Evidence map›Paper›PMID 38761081›Full record

ArticleJournal of the American Heart Association2024

Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias.

Joyce C Ohiri, Lisa Dellefave-Castillo, Garima Tomar, Lisa Wilsbacher, Lubna Choudhury, David Y Barefield, Dominic Fullenkamp, Anthony M Gacita, Tanner O Monroe, Lorenzo Pesce and 6 more

Abstract readCase Reports
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Joyce C OhiriCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.
Lisa Dellefave-CastilloCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0001-6044-0559
Garima TomarCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0009-0006-8423-2061
Lisa WilsbacherFeinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0002-3676-0680
Lubna ChoudhuryBluhm Cardiovascular Institute Northwestern Medicine Chicago IL USA.ORCID 0000-0003-4039-8490
David Y BarefieldCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0002-6166-640X
Dominic FullenkampCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0001-7627-7119
Anthony M GacitaCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.
Tanner O MonroeCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0001-9117-2227
Lorenzo PesceCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0002-8015-4653
Malorie BlancardDepartment of Pharmacology, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0003-1174-1069
Lauren VaughtCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0001-8634-9139
Alfred L GeorgeDepartment of Pharmacology, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0002-3993-966X
Alexis R DemonbreunCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.
Megan J PuckelwartzCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0002-0455-2983
Elizabeth M McNallyCenter for Genetic Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0002-1221-719X

Funding

Physiologic stress in advanced tissue culture models of cardiomyopathyK08HL163392 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Dominic Edward Fullenkamp · 2023 to 2026
$656k
Mechanisms linking the frail sarcomere to noncompaction cardiomyopathyK99HL168239 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MONROE, TANNER O · 2023 to 2024
$218k
CardioExcyte 96 system for pharmacology research at Northwestern UniversityS10OD026867 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2020 to 2020
$162k
NHLBI NIH HHS K08 HL163392NHLBI NIH HHS K99 HL168239NIH HHS S10 OD026867
6 · The paper itself

Abstract

backgroundMany cardiomyopathy-associated METHODS AND

resultsWe describe an individual with biallelic

conclusions

Indexed as

FilaminsProteostasisAdultArrhythmias, CardiacBortezomibCardiomyopathiesFemaleHumansInduced Pluripotent Stem CellsMaleMutationMyocytes, CardiacBortezomibFilaminsFLNC protein, humanarrhythmiaautophagyBAG3filamin Cproteostasis

Identifiers

PMID38761081
PMCPMC11179814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.