Evidence map›Paper›PMID 38761069›Full record

ArticleJournal of the American Heart Association2024

Comparison of Contemporary Treatment Strategies in Patients With Cardiogenic Shock Due to Severe Aortic Stenosis.

Raunak M Nair, Sanchit Chawla, Bahaa Abdelghaffar, Feras Alkhalaieh, Agam Bansal, Rishi Puri, James Yun, Amar Krishnaswamy, Samir Kapadia, Venu Menon and 1 more

Abstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Direct Comparison of Urgent Transcatheter Aortic Valve Implantation and Balloon Aortic Valvuloplasty: A Systematic Review and Meta-Analysis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Comparative Effectiveness of Balloon Aortic Valvuloplasty via Transradial and Transfemoral Access.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  9. Article
  10. Mechanical Circulatory Support as a Bridge to Transcatheter Aortic Valve Replacement in Cardiogenic Shock.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Raunak M NairCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0002-8939-141X
Sanchit ChawlaCleveland Clinic Foundation Internal Medicine Department Cleveland OH USA.
Bahaa AbdelghaffarCleveland Clinic Foundation Internal Medicine Department Cleveland OH USA.ORCID 0009-0008-2396-7296
Feras AlkhalaiehCleveland Clinic Foundation Internal Medicine Department Cleveland OH USA.
Agam BansalCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0002-6404-7436
Rishi PuriCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0001-8849-7426
James YunCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0003-2533-4253
Amar KrishnaswamyCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0001-6048-7955
Samir KapadiaCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0002-0026-3391
Venu MenonCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0003-4410-2677
Grant W ReedCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0001-8234-3135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aims of this study were to understand the incidence and outcomes of patients with cardiogenic shock (CS) due to severe aortic stenosis (AS), and the impact of conventional treatment strategies in this population. METHODS AND

resultsAll patients admitted to the Cleveland Clinic cardiac intensive care unit between January 1, 2010 and December 31, 2021 with CS were retrospectively identified and categorized into those with CS in the setting of severe AS versus CS without AS. The impact of various treatment strategies on mortality was further assessed. We identified 2754 patients with CS during the study period, of whom 216 patients (8%) had CS in the setting of severe AS. Medical management was associated with the highest 30-day mortality when compared with either balloon aortic valve replacement or aortic valve replacement (surgical or transcatheter aortic valve replacement) (hazard ratio, 3.69 [95% CI, 2.04-6.66];

conclusionsCS due to severe AS is associated with high in-hospital and 30-day mortality, worse compared with those with CS without AS. In suitable patients, urgent surgical aortic valvuloplasty or transcatheter aortic valve replacement is associated with favorable short- and long-term outcomes. Although balloon aortic valvuloplasty may be used to temporize patients with CS in the setting of severe AS, mortality is ≈50% if not followed by definitive aortic valve replacement within 90 days.

Indexed as

Aortic Valve StenosisSeverity of Illness IndexShock, CardiogenicTranscatheter Aortic Valve ReplacementAgedAged, 80 and overBalloon ValvuloplastyFemaleHeart Valve Prosthesis ImplantationHumansIncidenceMaleRetrospective StudiesRisk FactorsTime FactorsTreatment Outcomeaortic stenosisballoon aortic valvuloplastycardiac critical carecardiogenic shocktranscatheter aortic valve replacement

Identifiers

PMID38761069
PMCPMC11179830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.