Evidence map›Paper›PMID 38761052›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2024

Cost-Effectiveness of Pediatric Conjunctivitis Management and Return to Childcare and School Strategies: A Comparative Study.

Holly M Frost, Amy B Stein, Amy Keith, Timothy C Jenkins

Abstract readComparative Study
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Holly M FrostDepartment of Pediatrics, Denver Health and Hospital Authority, Denver, Colorado, USA.ORCID 0000-0002-3016-3287
Amy B SteinCenter for Health Systems Research, Denver Health and Hospital Authority, Denver, Colorado, USA.
Amy KeithCenter for Health Systems Research, Denver Health and Hospital Authority, Denver, Colorado, USA.
Timothy C JenkinsDivision of Infectious Diseases, Department of Medicine, Denver Health and Hospital Authority, Denver, Colorado, USA.

Funding

Rapid diagnostic tests for adenovirus conjunctivitis in children: An epidemiologic, clinical, and cost-effectiveness evaluationK23HD099925 · NICHD · DENVER HEALTH AND HOSPITAL AUTHORITY · PI FROST, HOLLY · 2019 to 2023
$762k
NICHD NIH HHS K23 HD099925
6 · The paper itself

Abstract

backgroundInfectious conjunctivitis affects 1 in 8 children annually, resulting in high ophthalmic antibiotic prescribing and absenteeism from childcare and school. We aimed to quantify the cost-effectiveness and annual savings of 3 evidence-based approaches to conjunctivitis management and return to childcare and school compared to usual care.

methodsUsing a decision analytic model from a societal perspective over a 1-year time horizon, we conducted a cost-effectiveness analysis of 3 management strategies for children aged 6 months to 17 years with non-severe conjunctivitis compared to usual care in the United States. Strategies accounted for rate of transmission. Strategies included (1) refraining from prescribing ophthalmic antibiotics for non-severe conjunctivitis, (2) allowing children without systemic symptoms to attend childcare and school, (3) and the combined approach of refraining from prescribing ophthalmic antibiotics and allowing children without systemic symptoms to attend childcare and school.

resultsThe estimated annual expenditure for pediatric conjunctivitis was $1.95 billion. Usual care was the most expensive ($212.73/episode), followed by refraining from ophthalmic antibiotic prescribing ($199.92) and allowing children without systemic symptoms to attend childcare and school ($140.18). The combined approach was the least costly ($127.38). Disutility was similar between approaches (quality-adjusted life days 0.271 vs 0.274). Refraining from antibiotic prescribing and the combination approach were dominant compared to usual care. The combined approach resulted in an estimated $783 million annual savings and 1.6 million ophthalmic antibiotic courses averted.

conclusionsConjunctivitis poses an economic burden that could be reduced by refraining from ophthalmic antibiotic use and allowing children without systemic symptoms to remain at school or childcare.

Indexed as

Anti-Bacterial AgentsCost-Benefit AnalysisAbsenteeismAdolescentChildChild CareChild, PreschoolConjunctivitisConjunctivitis, BacterialDecision Support TechniquesFemaleHumansInfantMaleSchoolsUnited StatesAnti-Bacterial Agentsantibiotic stewardshipconjunctivitiscost-effectivenessguidelinespediatrics

Identifiers

PMID38761052
PMCPMC11519041

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.