Evidence map›Paper›PMID 38760983›Full record

ArticleJournal of neuroendocrinology2024

The role of neuroestrogens in the estrogen-induced gonadotropin surge in male monkeys.

Mohammad S Biswas, Erica M Gelman, Daniel J Alexopoulos, Kim L Keen, Ryan J Adam, Ei Terasawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad S BiswasWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-1545-5521
Erica M GelmanWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Daniel J AlexopoulosWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kim L KeenWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Ryan J AdamWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-8602-8263
Ei TerasawaWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-3995-6643

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI KAUFMAN, PAUL L · 1985 to 2011
$106.7M
Towards Curative Therapies for Hypogonadotropic DiseasesR37HD043341 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI Stephanie Beth Seminara · 2020 to 2026
$5.8M
Role of neuroestradiol in regulation of the GnRH surgeR01HD089495 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI TERASAWA-GRILLEY, EI · 2018 to 2022
$2.1M
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R37HD043341Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD089495National Institutes of Health, Office of the Director, Office of Research Infrastructure Programs P51OD011106NCRR NIH HHS P51 RR000167NICHD NIH HHS R01 HD089495NICHD NIH HHS R37 HD043341NIH HHS P51 OD011106NIH HHS R01HD07747
6 · The paper itself

Abstract

Neuroestrogens locally synthesized in the brain are known to play a role in sexual behaviors. However, the question of whether neuroestrogens are involved in the regulation of the gonadotropin-releasing hormone (GnRH) release is just emerging. Because previous studies in this lab indicate that neuroestradiol is also important for the pulsatile release as well as the surge release of GnRH in female rhesus monkeys, in the present study, we examined whether neuroestradiol plays a role in the estrogen-induced LH surge in orchidectomized (ORX) male rhesus monkeys. Unlike in rodents, it is known that a high dose of estrogen treatment can result in the LH surge in ORX male rhesus monkeys. Results that the administration of the aromatase inhibitor, letrozole, failed to attenuate the estrogen-induced LH surge, suggest that unlike in ovariectomized females, neuroestrogens do not play a role in the LH surge experimentally induced by the exogenous estrogen treatment in ORX male monkeys.

Indexed as

EstrogensLuteinizing HormoneMacaca mulattaAnimalsAromatase InhibitorsEstradiolFemaleGonadotropin-Releasing HormoneLetrozoleMaleNitrilesOrchiectomyTriazolesAromatase InhibitorsEstradiolEstrogensGonadotropin-Releasing HormoneLetrozoleLuteinizing HormoneNitrilesTriazolesLH surgemale monkeyneuroestrogensex difference

Identifiers

PMID38760983
PMCPMC11444899

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.