ArticleBMC cancer2024
Associations between chronic obstructive pulmonary disease and ten common cancers: novel insights from Mendelian randomization analyses.
Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Restrictive lung function and smoking increase lung cancer risk in tuberculosis survivors: a cohort study.The Korean journal of internal medicine · 2026Article
- Article
- Marital status and competing risks of mortality in non-small cell lung cancer: a SEER-based nomogram analysis.Journal of thoracic disease · 2025Article
- Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study.Discover oncology · 2025Article
- Constructing multicancer risk cohorts using national data from medical helplines and secondary care.NPJ digital medicine · 2025Article
- Circulating white blood cell traits, chemokines and small cell lung cancer risk: a Mendelian randomization study.Translational cancer research · 2025Article
- LncRNA ZEB1-AS1 promotes the proliferation and migration of non-small cell lung cancer by activating epithelial-mesenchymal transition with STAT3.Translational cancer research · 2025Article
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Authors and funding
13 authors.
Funding
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Abstract
backgroundChronic obstructive pulmonary disease (COPD) is a significant global health issue, suspected to elevate the risk for various cancers. This study sought to discern whether COPD serves as a risk marker or a causative factor for prevalent cancers.
methodsWe employed univariable MR (UVMR) analyses to investigate the causal relationship between COPD and the top ten common cancers. Sensitivity analyses were performed to validate the main findings. Multivariable MR (MVMR) and two-step MR analyses were also conducted. False-discovery-rate (FDR) was used to correct multiple testing bias.
resultsThe UVMR analysis demonstrated notable associations between COPD and lung cancer (odds ratio [OR] = 1.42, 95%CI 1.15-1.77, FDR = 6.37 × 10
conclusionsCOPD appears to act more as a risk marker than a direct cause of prevalent cancers. Importantly, it partially mediates the connection between smoking and lung cancer, underscoring its role in lung cancer prevention strategies.
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