Evidence map›Paper›PMID 38760788›Full record

ArticleExperimental hematology & oncology2024

Analysis of CD20 and PD-L1 levels on small extracellular vesicles (sEV) produced by DLBCL cells and EBV-transformed B cells, and potential role in T cell inhibition.

Hussein Akil, Hafidha Bentayeb, Marine Aitamer, Chantal Vignoles, Julie Abraham, Nathalie Gachard, Agnès Olivrie, Anne Guyot, Jessica Gobbo, Jean Feuillard and 2 more

Registry-linked trialAbstract readLetter
In one paragraph

Article in Experimental hematology & oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03985696 (Exosomes and Resistance to Immunotherapy in Aggressive Non-Hodgkin B-cell Lymphomas), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03985696 nacompletednot on this map

Exosomes and Resistance to Immunotherapy in Aggressive Non-Hodgkin B-cell Lymphomas (B-NHL)

TypeinterventionalSponsorUniversity Hospital, LimogesRan2019 to 2025Enrolled90ConditionsLymphoma, B-cell, Aggressive Non-Hodgkin (B-NHL)Armsblood sample
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Role of Extracellular Vesicles in Epstein-Barr Virus Immunology and Pathogenesis for Possible Diagnostic and Therapeutic Direction.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  5. Article
  6. Article
  7. Extracellular vesicles in malignant and normal B lymphocyte growth and development.Extracellular vesicles and circulating nucleic acids · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hussein AkilCRIBL, UMR CNRS 7276 -INSERM U1262, CBRS, Université de Limoges, 2 Rue du Docteur Marcland, 87025, Limoges Cedex, France.
Hafidha BentayebCAPTuR UMR INSERM U1308, Facultés de Médecine et de Pharmacie, Université de Limoges, 2 Rue du Docteur Marcland, 87025, Limoges Cedex, France.
Marine AitamerCRIBL, UMR CNRS 7276 -INSERM U1262, CBRS, Université de Limoges, 2 Rue du Docteur Marcland, 87025, Limoges Cedex, France.
Chantal VignolesCRIBL, UMR CNRS 7276 -INSERM U1262, CBRS, Université de Limoges, 2 Rue du Docteur Marcland, 87025, Limoges Cedex, France.
Julie AbrahamCRIBL, UMR CNRS 7276 -INSERM U1262, CBRS, Université de Limoges, 2 Rue du Docteur Marcland, 87025, Limoges Cedex, France.
Nathalie GachardCRIBL, UMR CNRS 7276 -INSERM U1262, CBRS, Université de Limoges, 2 Rue du Docteur Marcland, 87025, Limoges Cedex, France.
Agnès OlivrieService d'Hématologie Clinique, CHU de Limoges, 2 Avenue Martin Luther King, 87000, Limoges, France.
Anne GuyotService d'Anatomie Pathologique, CHU de Limoges, 2 Avenue Martin Luther King, 87000, Limoges, France.
Jessica GobboINSERM 1231, Label Ligue National Contre le Cancer and Label d'excellence LipSTIC of Dijon; Early Phase Unit INCa CLIP, Anti-Cancer Center Georges-François Leclerc, Dijon, France.
Jean FeuillardCRIBL, UMR CNRS 7276 -INSERM U1262, CBRS, Université de Limoges, 2 Rue du Docteur Marcland, 87025, Limoges Cedex, France.
Hamasseh ShirvaniInstitut Roche, 30, Cours de L'île Seguin, 92650, Boulogne-Billancourt, France.
Danielle TroutaudCRIBL, UMR CNRS 7276 -INSERM U1262, CBRS, Université de Limoges, 2 Rue du Docteur Marcland, 87025, Limoges Cedex, France. danielle.troutaud@unilim.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence supports a role for small extracellular vesicles (sEV, including exosomes) in Diffuse Large B-cell lymphoma (DLBCL) progression and resistance to treatment. CD20 and PD-L1 are found on DLBCL-derived sEV, but little is known about their patient-level heterogeneity. Moreover, the capacity of PD-L1

Indexed as

CD20DLBCLExosomesHuman lymphoblastoid cell linesImmunosuppressionPD-L1sEVT cells

Identifiers

PMID38760788
PMCPMC11100054

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.