Evidence map›Paper›PMID 38760780›Full record

ArticleBMC cancer2024

The impact of loco-regional treatment modality on the outcomes in breast cancer patients younger than forty years of age.

Rimoun R Boutrus, Yasser A Abdelazim, Toka Mohammed, Mohammed Bayomy, Maher H Ibraheem, Alaadin Hussein, Medhat El Sebaie

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In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rimoun R BoutrusRadiation Oncology Department, National Cancer Institute, Cairo University, 1 Kasr El Aini Street, Fom El Khalig, Cairo, 11796, Egypt.
Yasser A AbdelazimRadiation Oncology Department, National Cancer Institute, Cairo University, 1 Kasr El Aini Street, Fom El Khalig, Cairo, 11796, Egypt. Yasser.anwar@nci.cu.edu.eg.
Toka MohammedRadiation Oncology Department, National Cancer Institute, Cairo University, 1 Kasr El Aini Street, Fom El Khalig, Cairo, 11796, Egypt.
Mohammed BayomyDepartment of Clinical Oncology, Zagazig University, Zagazig, Egypt.
Maher H IbraheemSurgical Oncology Department, Breast Division, National Cancer Institute, Cairo University, Cairo, Egypt.
Alaadin HusseinSurgical Oncology Department, Breast Division, National Cancer Institute, Cairo University, Cairo, Egypt.
Medhat El SebaieRadiation Oncology Department, National Cancer Institute, Cairo University, 1 Kasr El Aini Street, Fom El Khalig, Cairo, 11796, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the impact of the loco-regional treatment modality, on the loco-regional recurrence (LRR) rates and overall survival (OS) in breast cancer patients younger than 40 years.

methodsData of 623 breast cancer patients younger than 40 years of age were retrospectively reviewed. Patients were stratified according to the locoregional treatment approach into three groups: the mastectomy group (M), the mastectomy followed by radiation therapy group (MRX) and the breast conservative therapy group (BCT).

resultsMedian follow-up was 72 months (range, 6-180). Two hundred and nine patients were treated with BCT, 86 with MRM and 328 with MRX. The 10-year rate LRR rates according to treatment modality were: 13.4% for BCT, 15.1% for MRM and 8.5% for MRX (p 0.106). On univariate analysis, T stage (p 0.009), AJCC stage (p 0.047) and Her 2 status (p 0.001) were associated with LRR. Ten-year overall survival (OS) was 72.7% (78.5% in the BCT group, 69.8% in the MRM group and 69.8% in the MRX group, p 0.072). On Univariate analysis, age < 35 (p 0.032), grade III (p 0.001), N3 stage (p 0.001), AJCC stage III (p 0.005), ER negative status (0.04), Her 2-status positive (0.006) and lack of chemotherapy administration (p 0.02) were all predictors of increased mortality.

conclusionFor patients younger than 40 years of age, similar LRR and overall survival outcomes were achieved using BCT, M or MRX. Young age at diagnosis should not be used alone in recommending one loco-regional treatment approach over the others.

Indexed as

Breast NeoplasmsMastectomyNeoplasm Recurrence, LocalAdultAge FactorsCombined Modality TherapyFemaleFollow-Up StudiesHumansNeoplasm StagingRetrospective StudiesTreatment OutcomeYoung AdultBreast cancer in youngLocal controlLoco-regional treatmentPost mastectomy irradiation

Identifiers

PMID38760780
PMCPMC11100067

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.