Evidence map›Paper›PMID 38760616›Full record

ArticleEndocrine2024

Physical activity attenuates the excess mortality risk from prolonged sitting time among adults with osteoporosis or osteopenia.

Zhuoshuai Liang, Jia Lan, Xiaoyue Sun, Ruifang Guo, Yuyang Tian, Yujian Wang, Yawen Liu, Siyu Liu

Abstract read
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Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Association between weekend warrior physical activity pattern and bone mineral density among adults: national health and nutrition examination survey.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhuoshuai Liang *Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China.
Jia Lan *Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China.
Xiaoyue SunDepartment of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China.
Ruifang GuoDepartment of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China.
Yuyang TianDepartment of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China.
Yujian WangDepartment of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China.
Yawen LiuDepartment of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China. ywliu@jlu.edu.cn.
Siyu LiuDepartment of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun, 130021, China. liusiyu@jlu.edu.cn.

Funding

National Natural Science Foundation of China 11901234
6 · The paper itself

Abstract

purposeOsteoporosis is a common generalized skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. This study aims to crystallize associations of physical activity (PA) and sedentary behaviour with the survival of adults with osteoporosis or osteopenia.

methodsA total of 3103 participants aged 50 years or older from the National Health and Nutrition Examination Survey (NHANES) were included in the study. All participants were diagnosed with osteopenia or osteoporosis. Multivariable Cox proportional hazards regression models were used to assess the association of PA and sedentary behaviour with overall mortality, cancer-related mortality, and cardiovascular disease (CVD)-related mortality.

resultsDuring 21349 person-years of follow-up, 675 deaths were documented. Highly active participants had a lower risk of all-cause (hazard ratios [HR] = 0.61; 95% confidence interval [CI], 0.42-0.87; P for trend = 0.004), cancer-specific (HR = 0.64; 95%CI, 0.35-1.17; P for trend = 0.132), CVD-specific (HR = 0.75; 95%CI, 0.45-1.25; P for trend = 0.452), and other (HR, 0.51; 95%CI, 0.29-0.88; P for trend = 0.005) mortality than inactive participants. And sitting time was not associated with mortality among physically active participants; while among those who were insufficiently active or inactive, longer sitting time was associated with increased risks of all-cause (HR per 1-h increase = 1.05; 95% CI, 1.01-1.09), cancer-specific (HR per 1 h increase = 0.98; 95% CI, 0.90-1.07), CVD-specific (HR per 1-h increase = 1.11; 95% CI = 1.04-1.18), and other (HR per 1-h increase = 1.05; 95% CI, 0.98-1.13) mortality in a dose-response manner.

conclusionsPA can attenuate the excess mortality risk from prolonged sitting for individuals with osteoporosis and/or osteopenia. The combination of prolonged sedentary behaviour with inactive (participants without any PA during a week) PA was associated with an increased risk of mortality. The all-cause mortality risk of individuals who engage in less than 150 min/wk PA and sit more than 8 h/d is 2.02 (95% CI, 1.37-2.99) times higher than that of individuals who engage in more than 150 min/wk PA and sit less than 4 h/d.

Indexed as

Bone Diseases, MetabolicExerciseOsteoporosisSedentary BehaviorAgedCardiovascular DiseasesFemaleHumansMaleMiddle AgedNeoplasmsNutrition SurveysRisk FactorsSitting PositionBone mineral densityMortalityOsteoporosisPhysical activitySedentary behavior

Identifiers

PMID38760616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.