Evidence map›Paper›PMID 38760580›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2024

Point-of-care human milk concentration by passive osmosis: comprehensive analysis of fresh human milk samples.

Elizabeth R Schinkel, Elizabeth R Nelson, Jae H Kim, Maryanne T Perrin, Roger Dyer, Rajavel Elango, Lars Bode, David C Dallas, Jiraporn Lueangsakulthai, Carrie-Ellen Briere and 1 more

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elizabeth R SchinkelMother's Milk is Best Inc., R&D, 100 Business Park Drive, Unit #5, Tyngsboro, MA, 01879, USA. beth@mothersmilkisbest.com.ORCID 0000-0002-0002-3056
Elizabeth R NelsonMother's Milk is Best Inc., R&D, 100 Business Park Drive, Unit #5, Tyngsboro, MA, 01879, USA. elizabeth.nelson@mothersmilkisbest.com.ORCID 0009-0001-7523-793X
Jae H KimPerinatal Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.ORCID 0000-0001-6321-2594
Maryanne T PerrinDepartment of Nutrition, University of North Carolina Greensboro, Greensboro, NC, 27412, USA.ORCID 0000-0002-1645-8310
Roger DyerAnalytical Core for Metabolomics and Nutrition, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada.
Rajavel ElangoAnalytical Core for Metabolomics and Nutrition, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada.ORCID 0000-0002-9380-1725
Lars BodeBode Lab, Department of Pediatrics, School of Medicine, University of California, San Diego, San Diego, CA, 92093, USA.
David C DallasDallas Lab, Nutrition Program, College of Health, Oregon State University, Corvallis, OR, 97331, USA.
Jiraporn LueangsakulthaiDallas Lab, Nutrition Program, College of Health, Oregon State University, Corvallis, OR, 97331, USA.
Carrie-Ellen BriereBriere Lab, Elaine Marieb College of Nursing, University of Massachusetts Amherst, Amherst, MA, 01003, USA.ORCID 0000-0001-6622-7492
Sarah N TaylorDivision of Neonatology, Yale School of Medicine, New Haven, CT, 06520, USA.ORCID 0000-0002-6948-8329

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Human Milk Concentration Device; Point of Care Technology for Feeding Preterm Infants in Intensive CareR43HD098737 · NICHD · MOTHER'S MILK IS BEST, INC. · PI NELSON, ELIZABETH RANDALL, SCHINKEL, ELIZABETH RINALDI · 2019 to 2019
$224k
NCATS NIH HHS UL1 TR001863NICHD NIH HHS R43 HD098737
6 · The paper itself

Abstract

objectivePreterm infants need enrichment of human milk (HM) for optimal growth. This study evaluated a novel, point-of-care human milk concentration (HMC) process for water removal from fresh HM samples by passive osmotic concentration. STUDY

designNineteen fresh HM samples were concentrated by incubation with the HMC devices for 3 h at 4 °C. Pre- and post-concentration HM samples were compared by HM properties for: pH, osmolality, macronutrients, enzyme activity, bioactive, and total cell viability.

resultsPassive osmotic concentration reduced HM volume by an average of 16.3% ± 3.8% without a significant effect on pH or cell viability. Ten of the 41 HM components did not differ significantly (p > 0.05) between pre- and post-concentration samples. Twenty-three increased within the expected range by volume reduction. Six increased more than expected, two less than expected, and none decreased significantly.

conclusionPassive osmotic concentration of fresh HM can concentrate HM components by selective removal of water. HM osmolality and pH remained within neonatal feeding parameters.

Indexed as

Milk, HumanCell SurvivalFemaleHumansHydrogen-Ion ConcentrationInfant, NewbornInfant, PrematureOsmolar ConcentrationOsmosisPoint-of-Care Systems

Identifiers

PMID38760580
PMCPMC11518986

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.