SynthesisPediatric research2024
Risk factors and incidence of central venous access device-related thrombosis in hospitalized children: a systematic review and meta-analysis.
Synthesis in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Paediatric Central Venous Access Devices: An Evidence and Gap Map of Global Research.Journal of paediatrics and child health · 2026Pooled it
- Incidence of neonatal venous thromboembolism: a systematic review and meta-analysis of the literature.Research and practice in thrombosis and haemostasis · 2026Pooled it
- Venous Thromboembolism in Neonates, Children, and Adolescents: A Comprehensive Narrative Review of Risk Factors, Diagnosis, Treatment, and Prevention.Medicina (Kaunas, Lithuania) · 2026Review
- Looking Beyond Line Placement: Central Venous Catheter-Related Thrombosis in PICU.Indian pediatrics · 2026Article
- Incidence and Independent Risk Factors of Central Venous Catheter-Related Thrombosis in Critically Ill Children: A Prospective Study in Vietnam.Indian pediatrics · 2026Observational
- Septic pulmonary embolism in Somali children: a retrospective study from a tertiary hospital.Frontiers in pediatrics · 2026Article
- Two threats in early life: congenital hyperinsulinemic hypoglycemia and thrombosis.Therapeutic advances in endocrinology and metabolism · 2026Article
- Development of a risk prediction model for central venous catheter insertion-related thrombosis in critically ill pediatric patients.Frontiers in pediatrics · 2026Article
- Article
- Prevalence and risk factors of thrombosis in patients with congenital hyperinsulinism: a retrospective analysis.Frontiers in endocrinology · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risk factors for central venous access device-related thrombosis (CRT) in children are not fully understood. We used evidence-based medicine to find the risk factors for CRT by pooling current studies reporting risk factors of CRT, aiming to guide clinical diagnosis and treatment.
methodsA systematic search of PubMed, Web of Science, Embase, Cochrane Library, Scopus, CNKI, Sinomed, and Wanfang databases was conducted. RevMan 5.4 was employed for data analysis.
resultsThe review included 47 studies evaluating 262,587 children with CVAD placement. Qualitative synthesis and quantitative meta-analysis identified D-dimer, location of insertion, type of catheter, number of lumens, catheter indwelling time, and central line-associated bloodstream infection as the most critical risk factors for CRT. Primarily due to observational design, the quality of evidence was regarded as low certainty for these risk factors according to the GRADE approach.
conclusionBecause fewer high-quality studies are available, larger sample sizes and well-designed prospective studies are still needed to clarify the risk factors affecting CRT. In the future, developing pediatric-specific CRT risk assessment tools is important. Appropriate stratified preventive strategies for CRT according to risk assessment level will help improve clinical efficiency, avoid the occurrence of CRT, and alleviate unnecessary suffering of children. IMPACT: This is the latest systematic review of risk factors and incidence of CRT in children. A total of 47 studies involving 262,587 patients were included in our meta-analysis, according to which the pooled prevalence of CRT was 9.1%. This study identified several of the most critical risk factors affecting CRT in children, including D-dimer, insertion location, type of catheter, number of lumens, catheter indwelling time, and central line-associated bloodstream infection (CLABSI).
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