Evidence map›Paper›PMID 38760416›Full record

ArticleScientific reports2024

Chemogenetic activation or inhibition of histaminergic neurons bidirectionally modulates recognition memory formation and retrieval in male and female mice.

Alessia Costa, Eva Ducourneau, Lorenzo Curti, Alessio Masi, Guido Mannaioni, Lola Hardt, Essi F Biyong, Mylène Potier, Patrizio Blandina, Pierre Trifilieff and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alessia CostaDepartment of Neuroscience, Psychology, Drug Research and Child Health, Pharmacology and Toxicology Unit, University of Florence, Florence, Italy.
Eva DucourneauINRAE, Bordeaux INP, Nutrition and Integrative Neurobiology, UMR 1286, University of Bordeaux, 33077, Bordeaux, France.
Lorenzo CurtiDepartment of Neuroscience, Psychology, Drug Research and Child Health, Pharmacology and Toxicology Unit, University of Florence, Florence, Italy.
Alessio MasiDepartment of Neuroscience, Psychology, Drug Research and Child Health, Pharmacology and Toxicology Unit, University of Florence, Florence, Italy.
Guido MannaioniDepartment of Neuroscience, Psychology, Drug Research and Child Health, Pharmacology and Toxicology Unit, University of Florence, Florence, Italy.
Lola HardtINRAE, Bordeaux INP, Nutrition and Integrative Neurobiology, UMR 1286, University of Bordeaux, 33077, Bordeaux, France.
Essi F BiyongINRAE, Bordeaux INP, Nutrition and Integrative Neurobiology, UMR 1286, University of Bordeaux, 33077, Bordeaux, France.
Mylène PotierINRAE, Bordeaux INP, Nutrition and Integrative Neurobiology, UMR 1286, University of Bordeaux, 33077, Bordeaux, France.
Patrizio BlandinaDepartment of Neuroscience, Psychology, Drug Research and Child Health, Pharmacology and Toxicology Unit, University of Florence, Florence, Italy.
Pierre TrifilieffINRAE, Bordeaux INP, Nutrition and Integrative Neurobiology, UMR 1286, University of Bordeaux, 33077, Bordeaux, France.
Gustavo ProvensiDepartment of Neuroscience, Psychology, Drug Research and Child Health, Pharmacology and Toxicology Unit, University of Florence, Florence, Italy. gustavo.provensi@unifi.it.
Guillaume FerreiraINRAE, Bordeaux INP, Nutrition and Integrative Neurobiology, UMR 1286, University of Bordeaux, 33077, Bordeaux, France. guillaume.ferreira@inrae.fr.
M Beatrice PassaniDepartment of Health Sciences, Clinical Pharmacology and Oncology Unit, University of Florence, Florence, Italy. beatrice.passani@unifi.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several lines of evidence demonstrate that the brain histaminergic system is fundamental for cognitive processes and the expression of memories. Here, we investigated the effect of acute silencing or activation of histaminergic neurons in the hypothalamic tuberomamillary nucleus (TMN

Indexed as

NeuronsRecognition, PsychologyAnimalsFemaleHistamineHypothalamic Area, LateralMaleMental RecallMiceMice, Inbred C57BLHistamine

Identifiers

PMID38760416
PMCPMC11101472

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.