Evidence map›Paper›PMID 38760280›Full record

ArticleUltrasound in medicine & biology2024

Effect of Ambient Conditions on Acoustic Activation of the Perfluoropropane Droplets Within the Infarct Zone.

Shouqiang Li, Cheng Chen, John Lof, Elizabeth A Stolze, Jiri Sklenar, Xucai Chen, John J Pacella, Flordeliza S Villanueva, Terry O Matsunaga, E Carr Everbach and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shouqiang LiDepartment of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China; Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Cheng ChenUniversity of Pittsburgh Medical Center; Pittsburgh, PA, USA.
John LofDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Elizabeth A StolzeDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Jiri Sklenarnarnar.co, Lake Oswego, OR, USA.
Xucai ChenUniversity of Pittsburgh Medical Center; Pittsburgh, PA, USA.
John J PacellaUniversity of Pittsburgh Medical Center; Pittsburgh, PA, USA.
Flordeliza S VillanuevaUniversity of Pittsburgh Medical Center; Pittsburgh, PA, USA.
Terry O MatsunagaDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
E Carr EverbachDepartment of Engineering, Swarthmore College, Swarthmore, PA, USA.
Stanley J RadioDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Sherry WestphalDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Feng XieDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Xiaoping LengDepartment of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. Electronic address: xpleng@ems.hrbmu.edu.cn.
Thomas R PorterDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: trporter@unmc.edu.

Funding

Scar Detection and Treatment with Droplet ActivationR01HL146489 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PORTER, THOMAS R · 2020 to 2023
$3.0M
NHLBI NIH HHS R01 HL146489
6 · The paper itself

Abstract

backgroundAcoustically activated perfluoropropane droplets (PD) formulated from lipid encapsulated microbubble preparations produce a delayed myocardial contrast enhancement that preferentially highlights the infarct zones (IZ). Since activation of PDs may be temperature sensitive, it is unclear what effect body temperature (BT) has on acoustic activation (AA).

objectiveWe sought to determine whether the microvascular retention and degree of myocardial contrast intensity (MCI) would be affected by BT at the time of intravenous injection.

methodsWe administered intravenous (IV) PD in nine rats following 60 min of ischemia followed by reperfusion. Injections in these rats were given at temperatures above and below 36.5°C, with high MI activation in both groups at 3 or 6 min following IV injection (IVI). In six additional rats (three in each group), IV PDs were given only at one temperature (<36.5°C or ≥36.5°C), permitting a total of 12 comparisons of different BT. Differences in background subtracted MCI at 3-6 min post-injection were compared in the infarct zone (IZ) and remote zone (RZ). Post-mortem lung hematoxylin and eosin (H&E) staining was performed to assess the effect potential thermal activation on lung tissue.

resultsSelective MCI within the IZ was observed in 8 of 12 rats who received IVI of PDs at <36.5°C, but none of the 12 rats who had IVI at the higher temperature (p < 0.0001). Absolute MCI following droplet activation was significantly higher in both the IZ and RZ when given at the lower BT. H&E indicated significant red blood extravasation in 5/7 rats who had had IV injections at higher BT, and 0/7 rats who had IV PDs at <36.5°C.

conclusionsSelective IZ enhancement with AA of intravenous PDs is possible, but temperature sensitive. Thermal activation appears to occur when PDs are given at higher temperatures, preventing AA, and increasing unwanted bioeffects.

Indexed as

Contrast MediaFluorocarbonsMyocardial InfarctionRats, Sprague-DawleyAcousticsAnimalsBody TemperatureMaleMicrobubblesRatsContrast MediaFluorocarbonsperflutrenAcoustic activationBody temperatureDropletsImagingPerfluoropropane

Identifiers

PMID38760280
PMCPMC11189723

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.