Evidence map›Paper›PMID 38760174›Full record

ArticleLife science alliance2024

Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS.

Arun Pal, Dajana Grossmann, Hannes Glaß, Vitaly Zimyanin, René Günther, Marica Catinozzi, Tobias M Boeckers, Jared Sterneckert, Erik Storkebaum, Susanne Petri and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arun PalDivision for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Dajana GrossmannTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.
Hannes GlaßTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.
Vitaly ZimyaninDivision for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
René GüntherDivision for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Marica CatinozziDonders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands.
Tobias M BoeckersInstitute for Anatomy and Cell Biology, Ulm University, as well as Deutsches Zentrum für Neurodegenerative Erkrankungen, Ulm, Germany.
Jared SterneckertCenter for Regenerative Therapies Dresden, Technische Universität Dresden as well as Medical Faculty Carl Gustav Carus of TU Dresden, Dresden, Germany.ORCID 0000-0002-7688-3124
Erik StorkebaumDonders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands.ORCID 0000-0002-9519-5642
Susanne PetriDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Florian WegnerDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Stephan W GrillMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Francisco Pan-MontojoDepartment of Psychiatrie and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.
Andreas HermannTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany Andreas.Hermann@med.uni-rostock.de.ORCID 0000-0002-7364-7791

Funding

European Research Council
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) leads to death within 2-5 yr. Currently, available drugs only slightly prolong survival. We present novel insights into the pathophysiology of

Indexed as

Amyotrophic Lateral SclerosisGlycolatesLactic AcidMitochondriaProtein Deglycase DJ-1RNA-Binding Protein FUSSuperoxide Dismutase-1HumansLysosomesMembrane Potential, MitochondrialMotor NeuronsFUS protein, humanGlycolatesglycolic acidLactic AcidPARK7 protein, humanProtein Deglycase DJ-1RNA-Binding Protein FUSSOD1 protein, humanSuperoxide Dismutase-1

Identifiers

PMID38760174
PMCPMC11101837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.