Evidence map›Paper›PMID 38760173›Full record

ArticleLife science alliance2024

The F-actin bundler SWAP-70 promotes tumor metastasis.

Chao-Yuan Chang, Glen Pearce, Viktoria Betaneli, Tatsiana Kapustsenka, Kamran Hosseini, Elisabeth Fischer-Friedrich, Denis Corbeil, Jana Karbanová, Anna Taubenberger, Björn Dahncke and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chao-Yuan ChangInstitute for Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Glen PearceInstitute for Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Viktoria BetaneliInstitute for Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Tatsiana KapustsenkaInstitute for Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0009-0008-0313-8968
Kamran HosseiniCluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany.
Elisabeth Fischer-FriedrichCluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-2433-916X
Denis CorbeilBiotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Dresden, Germany.ORCID 0000-0003-1181-3659
Jana KarbanováBiotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Dresden, Germany.ORCID 0000-0001-7687-0983
Anna TaubenbergerBiotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Dresden, Germany.
Björn DahnckeInstitute for Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Martina RaunerDepartment of Medicine III and Center for Healthy Aging, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Giulia FuresiDepartment of Medicine III and Center for Healthy Aging, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Sven PernerInstitute of Pathology, University of Lübeck and University Hospital Schleswig-Holstein, Lübeck, Germany.
Fabian RostDRESDEN-concept Genome Center, Technology Platform at the Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.
Rolf JessbergerInstitute for Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany rolf.jessberger@tu-dresden.de.ORCID 0000-0002-2972-2192

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.

Indexed as

ActinsBreast NeoplasmsDNA-Binding ProteinsGuanine Nucleotide Exchange FactorsLung NeoplasmsMicrofilament ProteinsMinor Histocompatibility AntigensNeoplasm MetastasisActin CytoskeletonAnimalsCell AdhesionCell Line, TumorCell MovementCell ProliferationFemaleHumansActinsDNA-Binding ProteinsGuanine Nucleotide Exchange FactorsMicrofilament ProteinsMinor Histocompatibility AntigensNuclear ProteinsSWAP70 protein, humanSwap70 protein, mouse

Identifiers

PMID38760173
PMCPMC11101836

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.