Evidence map›Paper›PMID 38760116›Full record

ReviewInternational journal of radiation oncology, biology, physics2024

Imaging Assessment of Radiation Therapy-Related Normal Tissue Injury in Children: A PENTEC Visionary Statement.

John T Lucas, Zachary R Abramson, Katherine Epstein, Cara E Morin, Alok Jaju, Jessica W Lee, Chang-Lung Lee, Ranganatha Sitaram, Stephan D Voss, Melissa M Hudson and 2 more

Abstract readReview
In one paragraph

Review in International journal of radiation oncology, biology, physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

John T LucasDepartment of Radiation Oncology. Electronic address: johnthomas75@gmail.com.
Zachary R AbramsonDiagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee.
Katherine EpsteinDivision of Radiology and Medical Imaging, UC Department of Radiology, Cincinnati, Ohio.
Cara E MorinDivision of Radiology and Medical Imaging, UC Department of Radiology, Cincinnati, Ohio.
Alok JajuDepartment of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Jessica W LeeDepartment of Radiation Oncology and.
Chang-Lung LeeDepartment of Radiation Oncology and; Pathology, Duke University School of Medicine, Durham, North Carolina.
Ranganatha SitaramDiagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee.
Stephan D VossDepartment of Radiology, Harvard Medical School, Boston, Massachusetts.
Melissa M HudsonDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Louis S ConstineDepartment of Radiation Oncology, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York.
Chia-Ho HuaDepartment of Radiation Oncology.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

The Pediatric Normal Tissue Effects in the Clinic (PENTEC) consortium has made significant contributions to understanding and mitigating the adverse effects of childhood cancer therapy. This review addresses the role of diagnostic imaging in detecting, screening, and comprehending radiation therapy-related late effects in children, drawing insights from individual organ-specific PENTEC reports. We further explore how the development of imaging biomarkers for key organ systems, alongside technical advancements and translational imaging approaches, may enhance the systematic application of imaging evaluations in childhood cancer survivors. Moreover, the review critically examines knowledge gaps and identifies technical and practical limitations of existing imaging modalities in the pediatric population. Addressing these challenges may expand access to, minimize the risk of, and optimize the real-world application of, new imaging techniques. The PENTEC team envisions this document as a roadmap for the future development of imaging strategies in childhood cancer survivors, with the overarching goal of improving long-term health outcomes and quality of life for this vulnerable population.

Indexed as

Radiation InjuriesCancer SurvivorsChildDiagnostic ImagingHumansNeoplasmsOrgans at RiskRadiotherapy

Identifiers

PMID38760116
PMCPMC11684541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.