Evidence map›Paper›PMID 38760076›Full record

ArticleRNA (New York, N.Y.)2024

Transcription factors ERα and Sox2 have differing multiphasic DNA- and RNA-binding mechanisms.

Wayne O Hemphill, Halley R Steiner, Jackson R Kominsky, Deborah S Wuttke, Thomas R Cech

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wayne O Hemphill *Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80303, USA.ORCID 0000-0002-8136-1574
Halley R Steiner *Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80303, USA.ORCID 0000-0001-5212-1945
Jackson R Kominsky *Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80303, USA.
Deborah S WuttkeDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80303, USA thomas.cech@colorado.edu deborah.wuttke@colorado.edu.
Thomas R CechDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80303, USA thomas.cech@colorado.edu deborah.wuttke@colorado.edu.

Funding

RNA Regulation of Transcription Factor ActivityR01GM120347 · NIGMS · UNIVERSITY OF COLORADO · PI WUTTKE, DEBORAH S. · 2016 to 2024
$3.2M
Biophysical interrogation of the RNA-mediated mechanisms regulating Polycomb Repressive Complex 2 activityF32GM147934 · NIGMS · UNIVERSITY OF COLORADO · PI HEMPHILL, WAYNE OLIVER · 2022 to 2024
$213k
NIGMS NIH HHS F32 GM147934NIGMS NIH HHS R01 GM120347
6 · The paper itself

Abstract

Many transcription factors (TFs) have been shown to bind RNA, leading to open questions regarding the mechanism(s) of this RNA binding and its role in regulating TF activities. Here, we use biophysical assays to interrogate the

Indexed as

DNAEstrogen Receptor alphaProtein BindingRNASOXB1 Transcription FactorsBinding SitesHumansKineticsDNAESR1 protein, humanEstrogen Receptor alphaRNASOX2 protein, humanSOXB1 Transcription FactorsDNAkineticsRNAtranscription factor

Identifiers

PMID38760076
PMCPMC11251522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.