Evidence map›Paper›PMID 38759645›Full record

ArticleStem cell reports2024

Characterization of perivascular alveolar epithelial stem cells and their niche in lung homeostasis and cancer.

Qian Chen, Hiroyuki Hirai, Manwai Chan, Jilei Zhang, Minsu Cho, Scott H Randell, Preetish Kadur Lakshminarasimha Murthy, Jalees Rehman, Yuru Liu

Abstract read
In one paragraph

Article in Stem cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Cellular plasticity and regenerative mechanisms in the lung.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Journal of respiratory biology and translational medicine · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qian ChenDepartment of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Hiroyuki HiraiDepartment of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Manwai ChanDepartment of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Jilei ZhangDepartment of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Minsu ChoDepartment of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Scott H RandellMarsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Preetish Kadur Lakshminarasimha MurthyDepartment of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Jalees RehmanDepartment of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA; Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, IL 60607, USA; University of Illinois Cancer Center, Chicago, IL 60612, USA.
Yuru LiuDepartment of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA; Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA; University of Illinois Cancer Center, Chicago, IL 60612, USA. Electronic address: yuruliu@uic.edu.

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5M
The Lung Endothelium as an Instructive Niche for the Innate Immune System during Vascular InjuryP01HL160469 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jalees Rehman · 2022 to 2026
$14.0M
Synthetic Biology and Optogenetics CoreP01HL151327 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MEHTA, DOLLY · 2021 to 2025
$11.8M
Regulation of type II cells in the repair of alveolar epithelial injuryR01HL105947 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YURU LIU · 2012 to 2026
$5.7M
Mechanisms and Treatment of SARS-CoV-2 induced Lung Endothelial InjuryR01HL162308 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES, RICHNER, JUSTIN · 2022 to 2025
$2.9M
iPSC-Derived Vascularized Human Lung Organoids and Interaction Between Lung Endothelial Cells and Alveolar Epithelial CellsR01HL163978 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KADUR LAKSHMINARASIM, PREETISH, REHMAN, JALEES · 2022 to 2025
$2.9M
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung InjuryR01HL152515 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES · 2021 to 2024
$2.3M
Bioactive lipid mediated Endothelial niche regulation of alveolar epithelial repairR01HL155272 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIU, YURU · 2021 to 2024
$1.9M
NHLBI NIH HHS P01 HL151327NHLBI NIH HHS P01 HL160469NHLBI NIH HHS R01 HL105947NHLBI NIH HHS R01 HL152515NHLBI NIH HHS R01 HL155272NHLBI NIH HHS R01 HL162308NHLBI NIH HHS R01 HL163978NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

Lung alveolar structure and function are maintained by subsets of alveolar type II stem cells (AT2s), but there is a need for characterization of these subsets and their associated niches. Here, we report a CD44

Indexed as

Alveolar Epithelial CellsHomeostasisHyaluronan ReceptorsStem Cell NicheAnimalsEndothelial CellsLungLung NeoplasmsMiceSTAT1 Transcription FactorStem CellsHyaluronan ReceptorsSTAT1 Transcription FactoradventitialalveolicancerCD44homeostasisimmune signalinglungnichestem celltype II cells

Identifiers

PMID38759645
PMCPMC11390684

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.