Evidence map›Paper›PMID 38759377›Full record

ArticleNeoplasia (New York, N.Y.)2024

Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation.

Hannah R Ortiz, Paola Cruz Flores, Julia Podgorski, Aaron Ramonett, Tasmia Ahmed, Nadine Hempel, Pascale G Charest, Nathan A Ellis, Paul R Langlais, William R Montfort and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Menstrual blood-derived mesenchymal stem cell transplantation improves anti-fibrosis mechanisms in mouse models of alcoholic liver fibrosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hannah R OrtizDepartment of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
Paola Cruz FloresDepartment of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85724, USA.
Julia PodgorskiDepartment of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
Aaron RamonettDepartment of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
Tasmia AhmedDepartment of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85724, USA.
Nadine HempelDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Pascale G CharestDepartment of Molecular & Cellular Biology, University of Arizona, Tucson, AZ 85724, USA.
Nathan A EllisDepartment of Cellular & Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA.
Paul R LanglaisDepartment of Medicine, University of Arizona, Tucson, AZ 85724, USA.
William R MontfortDepartment of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85724, USA.
Karthikeyan MythreyeDepartment of Pathology, University of Alabama at Birmingham, AL 35294, USA.
Sanjay KumarDivision of Biology, Indian Institute of Science Education & Research Tirupati, Mangalam Tirupati 517507, India. Electronic address: sanjay@iisertirupati.ac.in.
Nam Y LeeDepartment of Pharmacology, University of Arizona, Tucson, AZ 85724, USA; Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85724, USA; Comprehensive Cancer Center, University of Arizona, Tucson, AZ 85724, USA. Electronic address: namlee@email.arizona.edu.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
The role and regulation of mTORC2 in cell migrationR01GM131200 · NIGMS · UNIVERSITY OF ARIZONA · PI CHAREST, PASCALE G · 2019 to 2023
$1.6M
Tumor-intrinsic and paracrine roles of endoglin in pancreatic cancerR01CA275036 · NCI · UNIVERSITY OF ARIZONA · PI Nam Y Lee · 2023 to 2026
$1.5M
TGF-beta signaling in mitochondrial dynamicsR35GM148171 · NIGMS · UNIVERSITY OF ARIZONA · PI Nam Y Lee · 2023 to 2026
$1.5M
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA275036NIGMS NIH HHS R01 GM131200NIGMS NIH HHS R35 GM148171
6 · The paper itself

Abstract

Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate the continuous remodeling of the ER network into sheets and tubules by coordinating with many ER-shaping protein complexes, although how this process is controlled by extracellular signals remains unknown. Here we report that TAK1, a kinase responsive to various growth factors and cytokines including TGF-β and TNF-α, triggers ER tubulation by activating αTAT1, an MT-acetylating enzyme that enhances ER-sliding. We show that this TAK1/αTAT1-dependent ER remodeling promotes cell survival by actively downregulating BOK, an ER membrane-associated proapoptotic effector. While BOK is normally protected from degradation when complexed with IP3R, it is rapidly degraded upon their dissociation during the ER sheets-to-tubules conversion. These findings demonstrate a distinct mechanism of ligand-induced ER remodeling and suggest that the TAK1/αTAT1 pathway may be a key target in ER stress and dysfunction.

Indexed as

Endoplasmic ReticulumMAP Kinase Kinase KinasesMicrotubulesSignal TransductionAcetylationAcetyltransferasesAnimalsEndoplasmic Reticulum StressHumansMAP Kinase Kinase Kinase 7MiceMicrotubule-Associated ProteinsMicrotubule ProteinsAcetyltransferasesATAT1 protein, humanMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMicrotubule-Associated ProteinsMicrotubule ProteinsAlpha TAT1BOKEndoplasmic reticulumMicrotubulesTAK1TGF-beta

Identifiers

PMID38759377
PMCPMC11127537

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.