ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2024
Clinical Presentation, Antimicrobial Resistance, and Treatment Outcomes of Aeromonas Human Infections: A 14-Year Retrospective Study and Comparative Genomics of 2 Isolates From Fatal Cases.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Twenty-two years ofNew microbes and new infections · 2026Article
- From Water to Bloodstream: Aeromonas dhakensis as an Emerging Cause of Catheter-Related Bloodstream Infection.Cureus · 2026Article
- Aeromonas dhakensis as an emerging invasive pathogen: a case series highlighting distinct carbapenem resistance and diagnostic challenge.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Article
- Establishment of a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry database and evaluation of different methods for cluster analysis of marine bacteria.Journal of medical microbiology · 2026Article
- Gastrointestinal infection caused by five different strains of Aeromonas caviae and one of Aeromonas veronii: case report and review of the literature.BMC infectious diseases · 2026Review
- Metatranscriptomic analyses of gut bacterial and viral communities in the critically endangered Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis) under distinct environments.Animal microbiome · 2026Article
- Species distribution, antimicrobial resistance, and putative virulence factor profiles ofFrontiers in microbiology · 2026Article
- Review
- A Unique Case of Aeromonas salmonicida Peritonitis in a Patient Undergoing Peritoneal Dialysis in Mexico.Cureus · 2025Article
- Clinical characteristics and antibiotic sensitivity & resistance analysis of cases of orthopedic infections caused by Aeromonas hydrophila.BMC musculoskeletal disorders · 2025Article
- Article
- Fulminant necrotizing fasciitis secondary toFrontiers in medicine · 2025Article
- Hydrogen gas therapy: A promising approach for sepsis management post-burn injury by modulating inflammation, oxidative stress, and wound healing.CytoJournal · 2025Article
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10 authors.
Funding
Abstract
backgroundAeromonas virulence may not be entirely dependent on the host's immune status. Pathophysiologic determinants of disease progression and severity remain unclear.
methodsOne hundred five patients with Aeromonas infections and 112 isolates were identified, their clinical presentations and outcomes were analyzed, and their antimicrobial resistance (AMR) patterns were assessed. Two isolates (A and B) from fatal cases of Aeromonas dhakensis bacteremia were characterized using whole-genome sequencing. Virulence factor- and AMR-encoding genes from these isolates were compared with a well-characterized diarrheal isolate A. dhakensis SSU and environmental isolate Aeromonas hydrophila American Type Culture Collection_7966T.
resultsSkin and soft tissue infections, traumatic wound infections, sepsis, burns, and intraabdominal infections were common. Diabetes, malignancy, and cirrhosis were frequent comorbidities. Male sex, age ≥ 65 years, hospitalization, burns, and intensive care admission were associated with complicated disease. High rates of AMR to carbapenems and piperacillin-tazobactam were found. Treatment failure was observed in 25.7% of cases. Septic shock and hospital-acquired infections were predictors of treatment failure. All 4 isolates harbored assorted broad-spectrum AMR genes including blaOXA, ampC, cphA, and efflux pumps. Only clinical isolates possessed both polar and lateral flagellar genes, genes for various surface adhesion proteins, type 3 and 6 secretion systems and their effectors, and toxin genes, including exotoxin A. Both isolates A and B were resistant to colistin and harbored the mobile colistin resistance-3 (mcr-3) gene.
conclusionsEmpirical therapy tailored to local antibiograms may facilitate favorable outcomes, while advanced diagnostic methods may aid in identifying correct Aeromonas spp. of significant clinical importance.
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