Evidence map›Paper›PMID 38759051›Full record

ArticleTechnology and health care : official journal of the European Society for Engineering and Medicine2024

Antigout effects and mechanisms of total flavonoids from prunus tomentosa.

Yanan Jiang, Chengyi Zhang, Xinyue Zhang, Na Lan, Zihan Zhao, Yawei Xv, Qi Wang, Siwei Wang, Baifeng Chen, Xi Chen and 1 more

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Article in Technology and health care : official journal of the European Society for Engineering and Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yanan JiangBeihua University, College of Basic Medicine, Jilin, China.
Chengyi ZhangBeihua University, College of Pharmacy, Jilin, China.
Xinyue ZhangJohns Hopkins University, Krieger School of Arts and Sciences, Washington, DC, USA.
Na LanMingZheng Forensic Identification Centre of Jilin, Jilin, China.
Zihan ZhaoBeihua University, College of Pharmacy, Jilin, China.
Yawei XvBeihua University, College of Pharmacy, Jilin, China.
Qi WangBeihua University, College of Basic Medicine, Jilin, China.
Siwei WangBeihua University, College of Basic Medicine, Jilin, China.
Baifeng ChenBeihua University, College of Basic Medicine, Jilin, China.
Xi ChenBeihua University, College of Basic Medicine, Jilin, China.
Yilin WangThe First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent years, hyperuricemia and acute gouty arthritis have become increasingly common, posing a serious threat to public health. Current treatments primarily involve Western medicines with associated toxic side effects.

objectiveThis study aims to investigate the therapeutic effects of total flavones from Prunus tomentosa (PTTF) on a rat model of gout and explore the mechanism of PTTF's anti-gout action through the TLR4/NF-κB signaling pathway.

methodsWe measured serum uric acid (UA), creatinine (Cr), blood urea nitrogen (BUN), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) levels using an enzyme-linked immunosorbent assay (ELISA). Histopathological changes were observed using HE staining, and the expression levels of relevant proteins were detected through Western blotting.

resultsAfter PTTF treatment, all indicators improved significantly. PTTF reduced blood levels of UA, Cr, BUN, IL-1β, IL-6, and TNF-α, and decreased ankle swelling.

conclusionsPTTF may have a therapeutic effect on animal models of hyperuricemia and acute gouty arthritis by reducing serum UA levels, improving ankle swelling, and inhibiting inflammation. The primary mechanism involves the regulation of the TLR4/NF-κB signaling pathway to alleviate inflammation. Further research is needed to explore deeper mechanisms.

Indexed as

FlavonoidsPrunusToll-Like Receptor 4Uric AcidAnimalsArthritis, GoutyBlood Urea NitrogenCreatinineDisease Models, AnimalGoutHyperuricemiaMaleNF-kappa BRatsRats, Sprague-DawleySignal TransductionCreatinineFlavonoidsNF-kappa BToll-Like Receptor 4Tumor Necrosis Factor-alphaUric Acidacute gouty arthritishyperuricemiaPrunus tomentosa total flavonesTLR4/NF-κB signaling pathway

Identifiers

PMID38759051
PMCPMC11191451

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.