Evidence map›Paper›PMID 38758997›Full record

ReviewJournal of Alzheimer's disease : JAD2024

A Multidimensional, Person-Centered Framework for Functional Assessment in Dementia: Insights from the 'What', 'How', 'To Whom', and 'How Much' Questions.

Andrea Slachevsky, Fabrissio Grandi, Daniela Thumala, Sandra Baez, Hernando Santamaria-García, Maureen Schmitter-Edgecombe, Mario A Parra

Abstract readReview
In one paragraph

Review in Journal of Alzheimer's disease : JAD, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Scientific knowledge about dementia: From the Global South to the world.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea SlachevskyGerosciences Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Fabrissio GrandiGerosciences Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Daniela ThumalaGerosciences Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Sandra BaezUniversidad de los Andes, Bogotá, Colombia.
Hernando Santamaria-GarcíaPhD Program of Neuroscience, Pontificia Universidad Javeriana, Bogotá, Colombia.
Maureen Schmitter-EdgecombeDepartment of Psychology, Washington State University, Pullman, WA, USA.
Mario A ParraDepartment of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Creating adaptive, wearable technologies to assess and intervene for individuals with ADRDsR35AG071451 · NIA · WASHINGTON STATE UNIVERSITY · PI COOK, DIANE JOYCE, SCHMITTER-EDGECOMBE, MAUREEN · 2021 to 2025
$4.4M
Multi-modal functional health assessment and intervention for individuals experiencing cognitive declineR01AG065218 · NIA · WASHINGTON STATE UNIVERSITY · PI COOK, DIANE JOYCE, SCHMITTER-EDGECOMBE, MAUREEN · 2020 to 2024
$3.3M
Research Training in Alzheimer's Disease and Brain Health in ColombiaD43TW012455 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIANA MATALLANA, Hernando Santamaria-Garcia · 2024 to 2026
$733k
FIC NIH HHS D43 TW012455NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG065218NIA NIH HHS R01 AG075775NIA NIH HHS R35 AG071451
6 · The paper itself

Abstract

Dementia is a syndrome characterized by cognitive and neuropsychiatric symptoms associated with progressive functional decline (FD). FD is a core diagnostic criterion for dementia, setting the threshold between its prodromal stages and the full-blown disease. The operationalization of FD continues to generate a great deal of controversy. For instance, the threshold of FD for the diagnosis of dementia varies across diagnostic criteria, supporting the need for standardization of this construct. Moreover, there is a need to reconsider how we are measuring FD to set boundaries between normal aging, mild cognitive impairment, and dementia. In this paper, we propose a multidimensional framework that addresses outstanding issues in the assessment of FD: i) What activities of daily living (ADLs) are necessary to sustain an independent living in aging? ii) How to assess FD in individuals with suspected neurocognitive disorders? iii) To whom is the assessment directed? and iv) How much does FD differentiate healthy aging from mild and major neurocognitive disorders? Importantly, the To Whom Question introduces a person-centered approach that regards patients and caregivers as active agents in the assessment process of FD. Thus, once impaired ADLs have been identified, patients can indicate how significant such impairments are for them in daily life. We envisage that this new framework will guide future strategies to enhance functional assessment and treatment of patients with dementia and their caregivers.

Indexed as

Activities of Daily LivingDementiaAgingCognitive DysfunctionHumansNeuropsychological TestsActivities of daily livingAlzheimer’s diseasedementiadisabilityfunctional abilityfunctional dependencefunctional independencefunctional statusperson-center care

Identifiers

PMID38758997
PMCPMC11178450

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.