Evidence map›Paper›PMID 38758809›Full record

SynthesisCancer2024

Interventions to mitigate cancer-related medical financial hardship: A systematic review and meta-analysis.

Ali Rashidi, Jinho Jung, Raymond Kao, Emily Lan Nguyen, Theresa Le, Brandon Ton, Wen-Pin Chen, Argyrios Ziogas, Gelareh Sadigh

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Persistent Financial Burden Among U.S. Cancer Survivors Despite Affordable Care Act Implementation: Implications for Survivorship Financial Education.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
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  16. Relationships between financial distress and anxiety and depression in cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ali RashidiDepartment of Radiological Sciences, University of California Irvine, Irvine, California, USA.
Jinho JungDepartment of Radiological Sciences, University of California Irvine, Irvine, California, USA.
Raymond KaoDepartment of Radiological Sciences, University of California Irvine, Irvine, California, USA.
Emily Lan NguyenDepartment of Radiological Sciences, University of California Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0001-5820-6990
Theresa LeDepartment of Radiological Sciences, University of California Irvine, Irvine, California, USA.
Brandon TonDepartment of Radiological Sciences, University of California Irvine, Irvine, California, USA.
Wen-Pin ChenChao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California, USA.
Argyrios ZiogasChao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California, USA.
Gelareh SadighDepartment of Radiological Sciences, University of California Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0003-3233-1878

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
NCI NIH HHS P30 CA062203NCI NIH HHS P30CA062203
6 · The paper itself

Abstract

backgroundThis study systematically reviewed interventions mitigating financial hardship in patients with cancer and assessed effectiveness using a meta-analytic method.

methodsPubMed, Cochrane, Scopus, CINAHL, and Web of Science were searched for articles published in English during January 2000-April 2023. Two independent reviewers selected prospective clinical trials with an intervention targeting and an outcome measuring financial hardship. Quality appraisal and data extraction were performed independently by two reviewers using a quality assessment tool. A random-effects model meta-analysis was performed. Reporting followed the preferred reporting items for systematic review and meta-analyses guidelines.

resultsEleven studies (2211 participants; 55% male; mean age, 59.29 years) testing interventions including financial navigation, financial education, and cost discussion were included. Financial worry improved in only 27.3% of 11 studies. Material hardship and cost-related care nonadherence remained unchanged in the two studies measuring these outcomes. Four studies (373 participants; 37% male, mean age, 55.88 years) assessed the impact of financial navigation on financial worry using the comprehensive score of financial toxicity (COST) measure (score range, 0-44; higher score = lower financial worry) and were used for meta-analysis. There was no significant change in the mean of pooled COST score between post- and pre-intervention (1.21; 95% confidence interval, -6.54 to 8.96; p = .65). Adjusting for pre-intervention COST, mean change of COST significantly decreased by 0.88 with every 1-unit increase in pre-intervention COST (p = .02). The intervention significantly changed COST score when pre-intervention COST was ≤14.5.

conclusionA variety of interventions have been tested to mitigate financial hardship. Financial navigation can mitigate financial worry among high-risk patients.

Indexed as

Financial StressNeoplasmsCost of IllnessFemaleHumansMaleMiddle AgedcancerCOST scorefinancial hardshipmeta‐analysissystematic review

Identifiers

PMID38758809
PMCPMC11347103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.