Evidence map›Paper›PMID 38758734›Full record

ArticleAnalytical chemistry2024

Comprehensive Two-Dimensional Liquid Chromatography-High-Resolution Mass Spectrometry for Complex Protein Digest Analysis Using Parallel Gradients.

Rick S van den Hurk, Bart Lagerwaard, Nathan J Terlouw, Mingzhe Sun, Job J Tieleman, Anniek X Verstegen, Saer Samanipour, Bob W J Pirok, Andrea F G Gargano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The benefits of multi-Analytical and bioanalytical chemistry · 2026
    Article
  2. Integrated Biomimetic 2D-LC and PermeapadMolecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rick S van den HurkAnalytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam1098 XH,The Netherlands.ORCID 0000-0002-1334-0480
Bart LagerwaardAnalytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam1098 XH,The Netherlands.
Nathan J TerlouwAnalytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam1098 XH,The Netherlands.
Mingzhe SunAnalytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam1098 XH,The Netherlands.
Job J TielemanAnalytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam1098 XH,The Netherlands.
Anniek X VerstegenAnalytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam1098 XH,The Netherlands.
Saer SamanipourAnalytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam1098 XH,The Netherlands.ORCID 0000-0001-8270-6979
Bob W J PirokAnalytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam1098 XH,The Netherlands.ORCID 0000-0002-4558-3778
Andrea F G GarganoAnalytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam1098 XH,The Netherlands.ORCID 0000-0003-3361-7341

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the high gain in peak capacity, online comprehensive two-dimensional liquid chromatography coupled with high-resolution mass spectrometry (LC × LC-HRMS) has not yet been widely applied to the analysis of complex protein digests. One reason is the method's reduced sensitivity which can be linked to the high flow rates of the second separation dimension (

Indexed as

Mass SpectrometryProteinsChromatography, LiquidHumansProteins

Identifiers

PMID38758734
PMCPMC11154668

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.