Evidence map›Paper›PMID 38758660›Full record

ArticleMolecular biology of the cell2024

A PACAP-activated network for secretion requires coordination of Ca

Xiaohuan Chen, Nicole A Bell, Breanna L Coffman, Agustin A Rabino, Rafael Garcia-Mata, Paul J Kammermeier, David I Yule, Daniel Axelrod, Alan V Smrcka, David R Giovannucci and 1 more

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Xiaohuan ChenDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.
Nicole A BellDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.
Breanna L CoffmanDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.
Agustin A RabinoDepartment of Biology, University of Toledo, Toledo, OH 43606.
Rafael Garcia-MataDepartment of Biology, University of Toledo, Toledo, OH 43606.
Paul J KammermeierDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY 14627.
David I YuleDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY 14627.
Daniel AxelrodDepartment of Physics and LSA Biophysics, and.
Alan V SmrckaDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109.
David R GiovannucciDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.
Arun AnantharamDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.ORCID 0000-0001-8560-6180

Funding

An experimental/computational approach for understanding salivary fluid secretionR01DE019245 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2008 to 2026
$9.7M
Understanding and Manipulating Phospholipase C and G Protein beta gamma subunit Signaling NetworksR35GM127303 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alan V. Smrcka · 2018 to 2026
$4.8M
Pre- and postsynaptic pathways underlying the stress response in the adrenal medullaR01NS122534 · NINDS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI ANANTHARAM, ARUN · 2021 to 2025
$1.8M
Regulation of epithelial junctions and lumen morphogenesis by the Scribble/SGEF/Dlg1 complexR01GM136826 · NIGMS · UNIVERSITY OF TOLEDO · PI GARCIA-MATA, RAFAEL · 2020 to 2023
$1.5M
Training in Molecular and translational Cell DynamicsT32GM144873 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI AVIDOR-REISS, TOMER, DWORKIN, LANCE DOUGLAS · 2022 to 2024
$1.3M
A novel system for controlling dimeric receptor composition to discover unique heterodimer pharmacologyR01MH125849 · NIMH · UNIVERSITY OF ROCHESTER · PI KAMMERMEIER, PAUL J. · 2023 to 2025
$1.2M
New Tools for Studying Receptor DimersR21NS126779 · NINDS · UNIVERSITY OF ROCHESTER · PI KAMMERMEIER, PAUL J., LUECK, JOHN D. · 2022 to 2023
$407k
NIDCR NIH HHS R01 DE019245NIGMS NIH HHS R01 GM136826NIGMS NIH HHS R35 GM127303NIGMS NIH HHS T32 GM144873NIMH NIH HHS R01 MH125849NINDS NIH HHS R01 NS122534NINDS NIH HHS R21 NS126779
6 · The paper itself

Abstract

Chromaffin cells of the adrenal medulla transduce sympathetic nerve activity into stress hormone secretion. The two neurotransmitters principally responsible for coupling cell stimulation to secretion are acetylcholine and pituitary adenylate activating polypeptide (PACAP). In contrast to acetylcholine, PACAP evokes a persistent secretory response from chromaffin cells. However, the mechanisms by which PACAP acts are poorly understood. Here, it is shown that PACAP induces sustained increases in cytosolic Ca

Indexed as

CalciumCalcium SignalingChromaffin CellsEndoplasmic ReticulumInositol 1,4,5-Trisphosphate ReceptorsPituitary Adenylate Cyclase-Activating PolypeptideAnimalsCalcium Channels, L-TypeCattleCalciumCalcium Channels, L-TypeInositol 1,4,5-Trisphosphate ReceptorsPituitary Adenylate Cyclase-Activating Polypeptide

Identifiers

PMID38758660
PMCPMC11244167

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.