SynthesisBJS open2024
Overall survival after mastectomy versus breast-conserving surgery with adjuvant radiotherapy for early-stage breast cancer: meta-analysis.
Synthesis in BJS open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07668362 (Clinicopathological Characteristics and Prognosis of Local Recurrence After Radical Mastectomy for Breast Cancer), which is not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinicopathological Characteristics and Prognosis of Local Recurrence After Radical Mastectomy for Breast Cancer: A Prospective Cohort Study
Who cites it
36 citing papers in PubMed.
- A multifunctional hydrogel dressing for wound healing and in vitro cytotoxicity against breast cancer cells: association with GRP78 expression.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Risk factors and predictive models for fat necrosis in DIEP flap breast reconstruction: A systematic review.JPRAS open · 2026Review
- Article
- Omission of intraoperative frozen section in sentinel lymph node biopsy for early breast cancer: impact on survival outcomes.Gland surgery · 2026Article
- Endoscopy‑assisted breast‑conserving treatment: the first Polish review of 30 patients.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2026Article
- Outcomes of Chest Wall Perforator Flaps for Partial Breast Reconstruction: A Single-Center, Single-Surgeon Experience.European journal of breast health · 2026Article
- Impact of supportive bra use and surgical factors on seroma and pain following breast-conserving surgery: a single-center retrospective study.Journal of medicine and life · 2026Article
- Patient-reported BREAST-Q Outcomes of Chest Wall Perforator Flaps in Partial Breast Reconstruction: A Single-center Experience.Plastic and reconstructive surgery. Global open · 2026Article
- Preoperative Radar Localisation of Impalpable Breast and Axillary Lesions: Initial Experience in an Australian Tertiary Centre.Journal of medical imaging and radiation oncology · 2026Article
- Minimally Invasive Nipple-Sparing Mastectomy: Early Experience With Endoscopic and Robotic Techniques.European journal of breast health · 2026Article
- Impact of body mass index on surgical outcomes and delay adjuvant treatment in patients undergoing therapeutic mammoplasty for breast cancer.JPRAS open · 2026Article
- Drivers of Variation in the Rate of Radiotherapy Following Lumpectomy in the Military Health System.Breast cancer (Dove Medical Press) · 2026Article
- Trends in use of magnetic resonance imaging and partial breast irradiation between 2011-2022 in the Netherlands: A population-based study.Clinical and translational radiation oncology · 2025Article
- Primary endocrine therapy versus surgery plus endocrine therapy for early-stage breast cancer in older women without frailty: a cost-effectiveness and value of implementation analysis.Health economics review · 2025Article
- Feasibility of a Green Breast Surgery Protocol to Reduce Carbon Footprint of Care: BuGS Trial Interim Results.Journal of clinical medicine · 2025Article
- Article
- Article
- National trends in neoadjuvant systemic therapy utilization in patients with early-stage HER2-positive breast cancer from 2016-2021: The impact of the KATHERINE trial.Breast cancer research and treatment · 2025Article
- Implication of indocyanine green angiography for chest wall perforator flap reconstruction in breast-conserving surgery.Gland surgery · 2025Article
- The prognostic differences between breast-conserving surgery and mastectomy in patients with invasive ductal carcinoma who achieved complete response following neoadjuvant chemotherapy: a propensity score matched analysis based on the SEER database.World journal of surgical oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundBreast-conserving surgery with adjuvant radiotherapy and mastectomy are currently offered as equivalent surgical options for early-stage breast cancer based on RCTs from the 1970s and 1980s. However, the treatment of breast cancer has evolved and recent observational studies suggest a survival advantage for breast-conserving surgery with adjuvant radiotherapy. A systematic review and meta-analysis was undertaken to summarize the contemporary evidence regarding survival after breast-conserving surgery with adjuvant radiotherapy versus mastectomy for women with early-stage breast cancer.
methodsA systematic search of MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), and Embase that identified studies published between 1 January 2000 and 18 December 2023 comparing overall survival after breast-conserving surgery with adjuvant radiotherapy versus mastectomy for patients with unilateral stage 1-3 breast cancer was undertaken. The main exclusion criteria were studies evaluating neoadjuvant chemotherapy, rare breast cancer subtypes, and specific breast cancer populations. The ROBINS-I tool was used to assess risk of bias, with the overall certainty of evidence assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool. Studies without critical risk of bias were included in a quantitative meta-analysis.
resultsFrom 11 750 abstracts, 108 eligible articles were identified, with one article including two studies; 29 studies were excluded from the meta-analysis due to an overall critical risk of bias, 42 studies were excluded due to overlapping study populations, and three studies were excluded due to reporting incompatible results. A total of 35 observational studies reported survival outcomes for 909 077 patients (362 390 patients undergoing mastectomy and 546 687 patients undergoing breast-conserving surgery with adjuvant radiotherapy). The pooled HR was 0.72 (95% c.i. 0.68 to 0.75, P < 0.001), demonstrating improved overall survival for patients undergoing breast-conserving surgery with adjuvant radiotherapy. The overall certainty of the evidence was very low.
conclusionThis meta-analysis provides evidence suggesting a survival advantage for women undergoing breast-conserving surgery with adjuvant radiotherapy for early-stage breast cancer compared with mastectomy. Although these results should be interpreted with caution, they should be shared with patients to support informed surgical decision-making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.