Evidence map›Paper›PMID 38758522›Full record

ArticleCancer causes & control : CCC2024

Cigarette smoking and prostate cancer aggressiveness among African and European American men.

Edgar T Ellis, Brian J Fairman, Shelbie D Stahr, Jeannette T Bensen, James L Mohler, Lixin Song, Eboneé N Butler, L Joseph Su, Ping-Ching Hsu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
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  11. Lifestyle medicine and prostate cancer: Time to look at the bigger picture?Indian journal of urology : IJU : journal of the Urological Society of India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Edgar T EllisDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, 4301 W Markham St., #820, Little Rock, AR, 72205-7190, USA.
Brian J FairmanDepartment of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Shelbie D StahrDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, 4301 W Markham St., #820, Little Rock, AR, 72205-7190, USA.
Jeannette T BensenLineberger Comprehensive Cancer Center and Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
James L MohlerDepartment of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA.
Lixin SongSchool of Nursing & Mays Cancer Center, University of Texas Health Science Center San Antonio, San Antonio, TX, 78229, USA.
Eboneé N ButlerDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
L Joseph SuPeter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Ping-Ching HsuDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, 4301 W Markham St., #820, Little Rock, AR, 72205-7190, USA. PHsu@uams.edu.

Funding

Genetic variability in DHFR and folic acid supplementation as novel risk factors for aggressive prostate cancerR15CA231510 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI SU, L. JOSEPH · 2018 to 2019
$565k
NCI NIH HHS R15 CA231510NCI NIH HHS R15CA231510U.S. Department of Defense W81XWH-21-1-0226
6 · The paper itself

Abstract

purposeSmoking is a modifiable lifestyle factor that has not been established as a prostate cancer risk factor, nor emphasized in prostate cancer prevention. Studies have shown that African American (AA) smokers have a poorer cancer prognosis than European Americans (EAs), while having a lower prevalence of heavy smoking. We examined the relationship between cigarette smoking and prostate cancer aggressiveness and assessed racial differences in smoking habits on the probability of high-aggressive prostate cancer.

methodsUsing data from the North Carolina-Louisiana Prostate Cancer Project (n = 1,279), prostate cancer aggressiveness was defined as high or low based on Gleason scores, serum prostate-specific antigen levels, and tumor stage. Cigarette smoking was categorized as current, former, or never smokers. Multivariable logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).

resultsSelf-reported current (OR = 1.99; 95% CI 1.30-3.06) smoking was associated with high-aggressive prostate cancer relative to never smokers. When stratified by self-reported race, the odds of having high-aggressive cancer increased among AA current (OR = 3.58; 95% CI 2.04-6.28) and former smokers (OR = 2.21; 95% CI 1.38-3.53) compared to AA never smokers, but the odds were diminished among the EA stratum (P

conclusionCigarette smoking is associated with prostate cancer aggressiveness, a relationship modulated by self-reported race. Future research is needed to investigate types of cigarettes smoked and metabolic differences that may be contributing to the racial disparities observed.

Indexed as

Black or African AmericanCigarette SmokingProstatic NeoplasmsWhiteAdultAgedHumansLouisianaMaleMiddle AgedNorth CarolinaRisk FactorsSmokingEpidemiologyHigh-aggressive prostate cancerRacial disparitiesTobacco use

Identifiers

PMID38758522
PMCPMC11377453

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.