ArticleInternational journal of bipolar disorders2024
A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder.
Article in International journal of bipolar disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older-Age Bipolar Disorder ISBD Task Forces.Bipolar disorders · 2026Pooled it
- Biomarkers for mood disorders: A scoping review of research from India.Indian journal of psychiatry · 2026Review
- Beyond Diagnosis: Transdiagnostic Cognitive Subgroups in Mood Disorders Linked to Work-Related Disability.Neuropsychopharmacology reports · 2026Article
- Machine Learning-Based Identification of Functional Dysregulation Characteristics in Core Brain Networks of Adolescents with Bipolar Disorder Using Task-fMRI.Diagnostics (Basel, Switzerland) · 2026Article
- Neural correlates of cognitive improvement over time in patients newly diagnosed with bipolar disorder.Neuroscience applied · 2026Article
- Occupational performance characteristics in patients with bipolar disorders: discriminant analysis with major depressive disorders.Frontiers in psychiatry · 2026Article
- The conundrum of the connection between severe psychiatric disorders and dementia.Dementia & neuropsychologia · 2025Review
- Neurocognitive function across different phases of bipolar disorder: an evaluation using the B-CATS.Frontiers in psychiatry · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBipolar disorder (BD) is a severe psychiatric disorder characterized by changes in mood that alternate between (hypo) mania or depression and mixed states, often associated with functional impairment and cognitive dysfunction. But little is known about biomarkers that contribute to the development and sustainment of cognitive deficits. The aim of this study was to review the association between neurocognition and biomarkers across different mood states.
methodSearch databases were Web of Science, Scopus and PubMed. A systematic review was carried out following the PRISMA guidelines. Risk of bias was assessed with the Newcastle-Ottawa Scale. Studies were selected that focused on the correlation between neuroimaging, physiological, genetic or peripheral biomarkers and cognition in at least two phases of BD: depression, (hypo)mania, euthymia or mixed. PROSPERO Registration No.: CRD42023410782.
resultsA total of 1824 references were screened, identifying 1023 published articles, of which 336 were considered eligible. Only 16 provided information on the association between biomarkers and cognition in the different affective states of BD. The included studies found: (i) Differences in levels of total cholesterol and C reactive protein depending on mood state; (ii) There is no association found between cognition and peripheral biomarkers; (iii) Neuroimaging biomarkers highlighted hypoactivation of frontal areas as distinctive of acute state of BD; (iv) A deactivation failure has been reported in the ventromedial prefrontal cortex (vmPFC), potentially serving as a trait marker of BD.
conclusionOnly a few recent articles have investigated biomarker-cognition associations in BD mood phases. Our findings underline that there appear to be central regions involved in BD that are observed in all mood states. However, there appear to be underlying mechanisms of cognitive dysfunction that may vary across different mood states in BD. This review highlights the importance of standardizing the data and the assessment of cognition, as well as the need for biomarkers to help prevent acute symptomatic phases of the disease, and the associated functional and cognitive impairment.
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