Evidence map›Paper›PMID 38758499›Full record

ReviewDrug delivery and translational research2025

Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment.

Chun Yi, Linzhu Lu, Zhaosheng Li, Qianqian Guo, Longyun Ou, Ruoyu Wang, Xuefei Tian

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chun YiDepartment of Pathology, Faculty of Medicine, Hunan University of Chinese Medicine, 410208, Changsha, Hunan, China.
Linzhu LuCollege of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Yuelu District, 410208, Changsha, Hunan Province, China.
Zhaosheng LiCollege of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Yuelu District, 410208, Changsha, Hunan Province, China.
Qianqian GuoCollege of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Yuelu District, 410208, Changsha, Hunan Province, China.
Longyun OuThe First Hospital of Hunan University of Chinese Medicine, 410208, Changsha, Hunan, China.
Ruoyu WangDepartment of Infectious Diseases, Department of Liver Diseases, The First Hospital of Hunan University of Chinese Medicine, 95 Shaoshan Rd, Hunan, 410208, Changsha, China. wrysky@live.com.
Xuefei TianCollege of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Yuelu District, 410208, Changsha, Hunan Province, China. 003640@hnucm.edu.cn.

Funding

Key Project of Academician Workstation Guidance Project 22YS002Key Projects of First-class Discipline of Integrated Traditional Chinese and Western Medicine 2021ZXYJH11Key Scientific Research Project of Hunan Education Department 21A0243National Natural Science Foundation of Changsha City kq2202271National Natural Science Foundation of China 82074450
6 · The paper itself

Abstract

Plant-derived exosome-like nanoparticles (PELNs) are natural nanocarriers and effective delivery systems for plant microRNAs (miRNAs). These PELN-carrying plant miRNAs can regulate mammalian genes across species, thereby increasing the diversity of miRNAs in mammals and exerting multi-target effects that play a crucial role in diseases, particularly cancer. PELNs demonstrate exceptional stability, biocompatibility, and targeting capabilities that protect and facilitate the up-take and cross-kingdom communication of plant miRNAs in mammals. Primarily ingested and absorbed within the gastrointestinal tract of mammals, PELNs preferentially act on the intestine to regulate intestinal homeostasis through functional miRNA activity. The oncogenesis and progression of cancer are closely associated with disruptions in intestinal barriers, ecological imbalances, as well as secondary changes, such as abnormal inflammatory reactions caused by them. Therefore, it is imperative to investigate whether PELNs exert their anticancer effects by regulating mammalian intestinal homeostasis and inflammation. This review aims to elucidate the intrinsic crosstalk relationships and mechanisms of PELNs-mediated miRNAs in maintaining intestinal homeostasis, regulating inflammation and cancer treatment. Furthermore, serving as exceptional drug delivery systems for miRNAs molecules, PELNs offer broad prospects for future applications, including new drug research and development along with drug carrier selection within targeted drug delivery approaches for cancer therapy.

Indexed as

ExosomesMicroRNAsNanoparticlesNeoplasmsAnimalsDrug Delivery SystemsHumansMicroRNAsCancer treatmentCross-kingdom regulationInflammationIntestinal homeostasismiRNA delivery systemsPlant-derived exosome-like nanoparticles

Identifiers

PMID38758499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.