Evidence map›Paper›PMID 38758471›Full record

ArticlePharmacological reports : PR2024

Tolerability of N-chlorotaurine in comparison with routinely used antiseptics: an in vitro study on chondrocytes.

Magdalena Pilz, Kevin Staats, Ojan Assadian, Reinhard Windhager, Johannes Holinka

Abstract readComparative Study
In one paragraph

Article in Pharmacological reports : PR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Activity ofInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Magdalena PilzDivision of Orthopaedics, Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. magdalena.pilz@meduniwien.ac.at.ORCID http://orcid.org/0009-0003-4370-8973
Kevin StaatsDivision of Orthopaedics, Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Ojan AssadianRegional Hospital Wiener Neustadt, Corvinusring 3-5, 2700, Wiener Neustadt, Lower Austria, Austria.
Reinhard WindhagerDivision of Orthopaedics, Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Johannes HolinkaDivision of Orthopaedics, Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, povidone-iodine (PVP-I) and hydrogen peroxide (H MATERIAL AND

methodsChondrocytes extracted from human cartilage were incubated with various concentrations of NCT, PVP-I, and H

resultsEZ4U kit showed after 5 and 30 min of incubation a significant decrease in cell viability at NCT 1%, NCT 0.1%, PVP-I, and H

conclusionOur results demonstrate that NCT is well tolerated by chondrocytes in vitro at the tested lower NCT concentrations 0.01% and 0.001% in contrast to the higher NCT concentrations 1% and 0.1%, PVP-I (1.1%), and H

Indexed as

Anti-Infective Agents, LocalCell SurvivalChondrocytesHydrogen PeroxidePovidone-IodineTaurineCells, CulturedDose-Response Relationship, DrugHumansAnti-Infective Agents, LocalHydrogen PeroxideN-chlorotaurinePovidone-IodineTaurineAntisepticsChondrocytesCytotoxicityN-ChlorotaurineSeptic joint infection

Identifiers

PMID38758471
PMCPMC11294436

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.