Evidence map›Paper›PMID 38758461›Full record

Trial reportBreast cancer research and treatment2024

BE-WEL trial (breast: evaluation of weight and exercise for lymphoedema) testing weight control and exercise programmes for women with breast cancer related lymphoedema: a feasibility trial.

Michelle Harvie, Karen Livingstone, Debbie McMulllan, Mary Pegington, Cheryl Lombardelli, Judith Adams, Maggie Farragher, Emma Barrett, Nigel Bundred

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michelle HarvieThe Nightingale and Prevent Breast Cancer Centre, Manchester University Hospital Foundation NHS Trust, Manchester, UK. Michelle.Harvie@manchester.ac.uk.ORCID http://orcid.org/0000-0001-9761-3089
Karen LivingstoneThe Nightingale and Prevent Breast Cancer Centre, Manchester University Hospital Foundation NHS Trust, Manchester, UK.
Debbie McMulllanThe Nightingale and Prevent Breast Cancer Centre, Manchester University Hospital Foundation NHS Trust, Manchester, UK.
Mary PegingtonThe Nightingale and Prevent Breast Cancer Centre, Manchester University Hospital Foundation NHS Trust, Manchester, UK.
Cheryl LombardelliThe Nightingale and Prevent Breast Cancer Centre, Manchester University Hospital Foundation NHS Trust, Manchester, UK.
Judith AdamsManchester Academic Health Science Centre and Radiology, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester Royal Infirmary, Manchester, UK.
Maggie FarragherTrafford Community, Manchester University Hospital Foundation NHS Trust, Manchester, UK.
Emma BarrettResearch and Innovation, Manchester University Hospital Foundation NHS Trust, Manchester, UK.
Nigel BundredDivision of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

Funding

MFT charitable funds TREH13
6 · The paper itself

Abstract

purposeA combined body weight loss and upper body/arm exercise programme is a potential strategy for managing Breast cancer related lymphoedema (BCRL), but there is limited data on the best method for delivery or its potential efficacy.

methodsFifty-seven women with overweight/obesity and BCRL were randomised to a 12 week supervised (n = 12) or home-based combined weight loss and upper body/arm exercise programme (n = 16), a home-based upper-body arm exercise only programme (n = 17) or standard care (n = 12). Primary outcomes were uptake, retention and changes in weight and change in Relative Arm Volume Increase (RAVI) using analysis of covariance (ANCOVA).

resultsSixteen percent of women invited joined the study and 49 completed the trial (85% retention). Reductions in weight occurred in the supervised and home-based weight control and exercise programmes; Mean (95% CI) change compared to standard care - 1.68 (- 4.36 to - 1.00), - 2.47(- 4.99 to - 0.04) Kg. Reductions in perometer assessed RAVI were seen in the supervised and home-based combined weight control and arm exercise groups and the weight stable home-based arm exercise only group: mean (95% CI) change compared to standard care - 2.4 (- 5.0 to + 0.4),- 1.8 (- 4.3 to + 0.7), - 2.5(- 4.9 to - 0.05)%.

conclusionWomen with BCRL and overweight and obesity engaged in diet and exercise weight loss programmes. Both weight loss/arm exercise programmes led to modest changes in weight and BCRL. Comparable reductions in BCRL were reported in the weight stable group undertaking arm exercise only. The independent and combined effects of weight loss and exercise on BCRL need further study.

trial registrationISRCTN86789850 https://doi.org/10.1186/ISRCTN86789850 , registered 2011.

Indexed as

Breast Cancer LymphedemaBreast NeoplasmsExercise TherapyObesityWeight LossAdultAgedExerciseFeasibility StudiesFemaleHumansLymphedemaMiddle AgedOverweightTreatment OutcomeWeight Reduction ProgramsBreast cancer related lymphoedemaObesityPerometerResistance exerciseWeight loss

Identifiers

PMID38758461
PMCPMC11230950

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.