Evidence map›Paper›PMID 38758422›Full record

ReviewDermatology and therapy2024

A Practical Approach to Diagnosing and Managing Chronic Spontaneous Urticaria.

Adam Friedman, Shawn G Kwatra, Gil Yosipovitch

Registry-linked trialAbstract readReview
In one paragraph

Review in Dermatology and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07680413 (Real-world Evaluation of the Effectiveness of Immunoglobulin-Histamine Complex; IHC), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07680413 recruitingnot on this mapstarted 2025, after this paper: background citation

Real-world Evaluation of the Effectiveness of Immunoglobulin-Histamine Complex; IHC (Histoglob) in the Management of Chronic Urticaria: A Prospective, Multicenter, Observational Study.

TypeobservationalSponsorBharat Serums and Vaccines LimitedRan2025 to 2026Enrolled600ConditionsChronic UrticariaArmsAntihistaminics, H2 blockers, Leukotriene antagonists, Immunoglobulin/Histamine Complex (IHC) Injection
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Targeting Mast Cells in Chronic Spontaneous Urticaria.Current allergy and asthma reports · 2026
    Review
  4. Article
  5. Article
  6. Prevalence, treatment and burden of chronic spontaneous urticaria in five European countries.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam Friedman *Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. ajfriedman@mfa.gwu.edu.ORCID http://orcid.org/0000-0001-8925-1620
Shawn G Kwatra *Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-3736-1515
Gil Yosipovitch *Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Coral Gables, FL, USA.ORCID http://orcid.org/0000-0001-6303-1822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic spontaneous urticaria (CSU) is an unpredictable inflammatory skin condition characterized by the spontaneous onset of itchy wheals, angioedema, or both, which occurs for longer than 6 weeks overall. Despite the relatively straightforward diagnostic algorithm for CSU, relying primarily on a detailed medical history and only limited laboratory tests, patients often wait years to be diagnosed, with many cycling through different healthcare practitioners before a diagnosis is made. Even then, current treatment options for CSU are limited, with approximately half of patients resistant to standard-of-care second-generation antihistamines at standard or higher doses. As such, there is an unmet need for improved, streamlined management for patients with CSU. Here, we review the evidence-based diagnostic algorithm for CSU, consider the required steps of the diagnostic workup, and provide practical, real-world advice on the management of CSU to improve the timely diagnosis and care of patients with this debilitating disease.

Indexed as

AngioedemaChronic spontaneous urticariaChronic urticariaDiagnosisWheals

Identifiers

PMID38758422
PMCPMC11169305

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.